Endocrine Research Updates

For Medical Professionals

Prescription Medicine Bottles
Nearly 40% of elderly use 5 or more medications
Overall prescription drug use increased 9% among U.S. adults between 1999 and 2012, according to data from the National Health and Nutrition Examination Survey.
Dental X-Ray
While exposure to the standard therapy for XLH has no apparent benefit on enthesopathy, there is some benefit to oral health in adults.
Exposure to standard therapeutic regimen for X-linked hypophosphatemia (XLH) of calcitriol and phosphate has no effect on enthesopathy but is protective of dental health.
Overweight, obese female, knees bent, on scale weighing herself
Mechanisms related to excessive weight gain have a deleterious effect on the development and management of osteoarthritis (OA).
Obesity is a long-known major risk factor for osteoarthritis. Now, scientists are uncovering new information about just how risky excess weight is for joints. They're also discovering other mechanisms besides obesity that may drive risk.
Side view of the human brain and prefrontal cortex
Neuromodulation targeting the dorsolateral prefrontal cortex (LDLPFC) decreased calorie consumption and increased weight loss in adults with obesity, according to a recent study.
measuring an overweight man's waist size using a measuring tape
Highlight from ObesityWeek 2015
During ObesityWeek 2015, Melissa Crane, PhD explained men aren't attracted to typical weight loss programs, viewing them as complicated and tailored to women. They want simplified weight loss programs and want to lose weight for health reasons.
middle age couple, overweight, dieting
Adults ages 40 to 70 years who are overweight or obese and do not have symptoms of diabetes should be screened for abnormal blood glucose levels as part of an overall cardiovascular risk assessment, according to a recommendation statement issued by the U.S. Preventive Services Task Force.
pill molecules helds in a gloved hand
Only 2% of the millions of Americans who are eligible for chronic weight management medications are prescribed these agents and only 1% of the millions of Americans who are eligible for bariatric surgery receive this intervention.
Coins in the Air
This study is the first to examine real-world data on the long-term effect of bariatric surgery on healthcare costs in obese patients according to their diabetes status.
Type 1 diabetes
Released by JDRF, the Endocrine Society, and the American Diabetes Association
A new approach for staging T1D in its earliest presymptomatic stages was released by the JDRF, the Endocrine Society, and the American Diabetes Association. The organizations endorse the concept that autoimmune disease precedes the onset of symptoms and progresses through distinct stages.
Summary of the American Association of Clinical Endocrinologists position statement questioning recent studies that suggest use of testosterone replacement therapy (TRT) increases the risk of cardiovascular events.
Steroid Hormone
Aldosterone is a new target for treating hypertension not only in patients with primary aldosterone, but also in a cohort of patients without primary aldosterone who were thought to have essential hypertension up to now.
Boy and Girl
Transgender identity and hormone treatment
A single educational lecture on transgender identity and hormone treatment regimens increased internal medicine and family medicine residents’ knowledge and willingness to assist with hormonal therapy.
Outcomes based on Afirma and cytologically benign thyroid diseases are similar.
Findings suggest that Cyto-I/GEC-B nodules shows comparable clinical behavior to cytologically benign nodules and may be conservatively monitored.
man in front of refrigerator
Healthy men fed approximately 6,000 calories per day for 1 week experienced rapid weight gain as well as systemic and adipose tissue insulin resistance and oxidative stress, demonstrating for the first time in vivo a direct relationship between excessive nutrient intake and the development of insulin resistance.
Child's Hand on Adult Hand
A Q&A with A. Jay Cohen, MD
EndocrineWeb provides a Q&A with A. Jay Cohen, MD summarizing his presentation made during AACE in May 2015. Here he discusses the challenges that arise during the transition from adolescent to adult care among patients with endocrine disorders.
Elderly Woman Reading Warning Labels on Pill Bottles
The FDA has strengthened the warning regarding an increased risk for bone fractures and decreased bone mineral density for the type 2 diabetes medication canagliflozin (Invokana, Invokamet), and added a new item to Warnings and Precautions section and revised the Adverse Reactions section of the prescribing information.
cross section of a human kidney
While impaired renal function is considered a barrier to use of bisphosphonates, the researchers found that measures of renal function remained stable or improved slightly following use of pamidronate.
boy eating apple
A minority of adults and caregivers of children with type 1 diabetes routinely download and review data from diabetes devices, according to data from a cross-sectional survey published in Diabetes Technology and Therapeutics.
pituitary-thyroidal axis
Conflicting data have led to uncertainly regarding the association between mild thyroid failure and cognitive function. In the first-ever systematic review and meta-analysis, researchers found a possible link between subclinical hypothyroidism and cognitive impairment in individuals younger than 75 years of age and in those with higher thyroid stimulating hormone levels. James V. Hennessey, MD provides insightful commentary.
dumb bells, measuring tape, water bottle, medication for weight management
Liraglutide 3.0 mg once daily as an adjunct to a reduced-calorie meal plan and physical activity was associated with clinically meaningful and sustained weight loss in a 56-week, randomized, double-blind trial involving more than 3,700 patients who were overweight or obese.