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Endocrine Research Updates

For Medical Professionals

Radioactive iodine preferred treatment for Graves' hyperthyroid disease.
Mayo Clinic Study found that RAI was favored over antithyroid medications and thyroidectomy, offering the best outcome for this most common form of hyperthyroid disease, among this group of patients.
Testosterone replacement offers little benefit for aging men.
EndocrineWeb highlights results of the last 2 of 7 studies—looking at the effects of testosterone replacement for anemia and bone strength in older men with low circulating hormone levels—from the National Institutes of Health (NIH) sponsored Testosterone Trials (TTrials).
No benefits found from testosterone supplementation in aging men.
Seeking confirmation of efficacy, results from 2 of the 4 testosterone trials (TTrials) are highlighted to address the growing practice of boosting low testosterone in men. This brief focuses on the findings of testosterone supplementation to achieve improved outcomes in Alzheimer’s disease and cardiovascular disease.
Identifying factors that may improve treatment for people with Graves' disease.
In an effort to tease out possible factors that might predict relapse, a team of researchers from the University of Buffalo conducted a meta-analysis of studies published over nearly 4 decades, encompassing more than 4000 patients treated for hyperthyroid disease.
Health outcomes improve when clinicians involve patients in treatment decisions
Individualizing care, rather than following guidelines and clinical recommendations uncritically, will improve disease management and reduce costs without compromising outcomes, according to researchers who evaluated current practice.
New ADA guidelines focus on prevention and screening for diabetic neuropathy.
Updated position statement issued by the American Diabetes Association for managing diabetic neuropathies focused on preventing and early screening as the primary goals.
Beyond genetics, DNA methylation is identified as a new factor in obesity
DNA methylation may join body mass index, adiposity, and gene expression as another factor that predisposes certain individuals to develop obesity, obesity-related conditions.
PES issues new guidelines to clarify when to treat children with short stature
Pediatric Endocrine Society offers updated recommendations for use of growth-promoting hormone therapy and related medications in children.
Combination therapy, not insulin, provides better long-term outcomes for T2D.
85% of patients with type 2 diabetes who received concurrent treatment with exenatide and pioglitazone achieved the ADA-recommended HBA1c goal of <7.0%, with fewer hypoglycemic incidents and less weight gain, achieving clinically improved outcomes over patients taking insulin.
Women can reduce chronic disease risks with regular strength training.
Women can reduce their risk of diabetes and other chronic conditions simply by incorporating resistance exercise into a weekly physical activity plan, according to the National Institute on Aging.
Metformin may alter gut micrflora, leading to improved glucose metabolism in T2D
Given the strength of the findings, people who take metformin for their diabetes appear to have an enriched gut microflora that fosters a more efficient response to glucose metabolism.
Clinical training and sensitivity to transgender patients needs improvement.
Lack of training for gender-affirming patients identifid; medical interventions, while not complex, require more than simply giving estrogen or testosterone.
Autotaxin, a spinal fluid enzyme, may predict risk of Alzheimers, Diabetes.
Evaluating levels of autotaxin, an enzyme found in the fluid around the brain and spine, may be useful in identifying those at risk of cognitive decline and type 2 diabetes, Iowa researchers find.
The 2017 guidelines, issued after 6 years of new evidence and experience, offer more targeted recommendations for clinical management of women who have thyroid disease once they become pregnant as well as postpartum. Four key changes in the new guidelines are highlighted.
Elevating the predictive accuracy of biopsy node assessment may be possible using both a highly specific oncogene panel and a classification test for miRNA gene expression to improve surgical decision-making.
Improving sleep by adjusting work-shifts to fit a person's chronotype may be the most effective approach to address resistant diabetes or creeping obesity.
To provide the most effective care for patients with diabetes, EndocrineWeb editorial board members consider the barriers to care from individualized care planning and a change to prevention over fee-for-serve care, to integrating obesity strategies into diabetes management.
When surgery is not an option for hyperparathyroid disease, try thiazides.
When surgery is not an option, thiazide diuretics--an old drug class with complicated side effects--may offer an effective alternative for some patients.
Annual review of standards has many firsts, including the need to individualize treatment with a focus on staging diabetes; addressing obesity, sleep, mental health; and, accounting for patient costs in treatment to achieve the best outcomes for people at risk of or having diabetes.
Cannabis is known to have a positive role in reducing pain but its effect on metabolism and the endocrine system appear less favorable. Researchers examined the use of cannabis in thyroid function, finding a significantly elevated TSH among current users who were typically young males whose risk of thyroid or diabetes is low.
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