Endocrine Research Updates

For Medical Professionals

In diabetes, poor glucose control may be a sign of hepatitis C.
Therapeutic identification and treatment of the hepatitis C virus may address otherwise unexplained and erradic changes in blood glucose, improving management in people with type 2 diabetes.
The way physicians order thyroid labs is highly variable.
Ordering the appropriate thyroid panel is wrong 30% of the time, and the right tests are missed equally as often, prompting discussion of need for clearer guidelines, and reliance on individualized care, in the meantime.
Significant variation was found in thyroid testing practices, suggesting a possible need for better guidelines to improve consistency.
Metformin doesn't provide cardiovascular benefits for people with diabetes.
While metformin didn't reduce the risk of atherosclerosis in people with type 1 diabetes as anticipated, secondary outcomes offered more promise, according to findings from the REMOVAL trial.
Levothyroxine Ineffective as treatment for Subclinical Hypothyroidism in seniors
Thyroid replacement therapy lowered thyrotropin levels in elderly patients, but treatment did not relieve any symptoms of hypothyroidism.
For poorly controlled diabetes, ertugliflozin may help control glucose.
Preliminary data for investigational ertugliflozin suggests favorable outcomes for people with recalcitrant type 2 diabetes despite improvements in physical activity and diet.
Thyroidectomy by a seasoned surgeon gives best outcome for Grave's disease
Total thyroidectomy is underutilized but promises the best outcomes for Grave's disease, but the risk of serious complications is high, necessitating referral to a highly trained surgeon.
Thyroid hormone levels may predict best diet for successful weight loss.
As regulators of metabolism, thyroid hormones help explain why some individuals lose weight while others don't on any given weight-loss regime.
Even in adults with normal thyroid function, these hormones play a role in body weight regulation and may help identify individuals more responsive to a dietary intervention aimed at promoting weight loss, and those who are deemed unresponsive may be better candidates for bariatric surgery.
Transgender Youth Benefit from Puberty Suppression
Clinical support for puberty suppression often improves emotional wellbeing during a time of sexual uncertainty and may ease feelings of gender incongruence.
Cannabis compound may have impact on diabetes.
Examining the effects of an endogenous cannabinoid uncovered a dual response in the pathways that regulate inflammatory response in the gut.
Aflibercept Injections preferred over laser surgery for treatment of Diabetic Re
Injections with a monoclonal antibody therapy, Eylea, provided superior results and outperformed laser surgery for treatment of diabetic retinopathy.
New bone-building agent, TYMLOS (abaloparatide) approved by FDA for older women
TYMLOS (abaloparatide), a new bone-building anabolic therapeutic agent for high fracture risk, older women, including those with diabetes or thyroid disease, gains Food and Drug Administration approval.
National Diabetes Prevention Program effective in reducing diabetes risk.
Participating in a structured lifestyle program with regularly attended sessions promotes improved eating habits and commitment to exercise forestallling diabetes risks.
Multimodal approach promises the best outcomes for Cushing's disease.
To achieve long-term remission, clinicians should anticipate the need for additional treatment following surgery for Cushing's disease in 25% of patients.
Diabetic Ketoacidosis Looks Like Type 2 Diabetes in African American.
In African Americans, men, and other minorities, ketosis-prone diabetes appears more consistent with type 2 diabetes but responds to insulin as if type 1 diabetes.
Woman learning to use the newly FDA approved iSage Rx self-management insulin ti
iSage Rx is the only prescription-required mobile platform designed to guide patients in basal insulin titration and health self-management.
Risk of cognitive decline increases with onset of prediabetes.
Early, aggressive treatment for insulin resistance (prediabetes) in middle-aged individuals with cardiovascular disease greatly reduces the risk of advancing cognitive function.
Experts consider moving towardtreat-to-target approach to tackling osteoporosis.
The move to a more goal-oriented, patient-centered approach to osteoporosis treatment was presented during the Clinical Osteoporosis 2017 conference.
Lipoprotein(a) suggests greater risk for inherited heart disease with diabetes.
From PROMIS, genetic variants that were exclusively associated with apoprotein(a) size and concentration provide further indication that lowering the lipoprotein(a) concentration may be a strategy to reduce cardiovascular disease risk.
Check for hypertension in individuals under age 40 with an endocrine disorder.
Evaluating patients with an endocrine-related disorder, particularly those under age 40 who present with high blood pressure, is critical to ensure treatment is provided to life-saving effect.
Dual Gene Mutations predict outcomes of aggressive thyroid cancer.
Papillary thyroid cancer is the most common form, and highly curable, but up to 20% of cases have a high rate of rapid growth and recurrence; genetic testing can improve their detection with greater chance for effective treatment.