Endocrine Research Updates

For Medical Professionals

Seniors with diabetes at 17-fold increased risk for falls.
Individuals with diabetes require greater vigilance from clinicians to elicit lifestyle changes aimed at reducing risk for future falls, a challenge that will increase with age.
Do we need legislation to designate September as PCOS month?
While the National Polycystic Ovary Syndrome Association seeks to raise attention for PCOS, their efforts are not aligned with a recent NIH report on the condition.
Cornell researchers offer insight into bone changes behind atypical fractures.
Researchers offer clearer understanding of the changes that occur in bone structure following treatment with bisphosphonates that may be behind the rare, atypical fractures.
Alzheimer's drug improves insulin response and reduces inflammation in obesity.
A medication used to treat dementia demonstrated anti-inflammatory action that improved insulin sensitivity and other markers of inflammation in obese patients.
Medication used to treat Alzheimer's disease improves insulin sensitivity and markers of inflammation in metabolic syndrome.
People with significant visceral fat may benefit from anti-inflammatory therapy.
The anti-inflammatory asthma and allergy medication, amlexanox, significantly reduced HbA1c, CRP, insulin resistance, and fatty liver in a subset of people with type 2 diabetes.
A healthy lIfestyle can reduce the risk of diabetes and osteoporosis later.
Evidence-based recommendations for optimal comanagement of patients with diabetes and bone loss, stresses the need to initiate treatment early.
In diabetes, poor glucose control may be a sign of hepatitis C.
Therapeutic identification and treatment of the hepatitis C virus may address otherwise unexplained and erradic changes in blood glucose, improving management in people with type 2 diabetes.
The way physicians order thyroid labs is highly variable.
Ordering the appropriate thyroid panel is wrong 30% of the time, and the right tests are missed equally as often, prompting discussion of need for clearer guidelines, and reliance on individualized care, in the meantime.
Significant variation was found in thyroid testing practices, suggesting a possible need for better guidelines to improve consistency.
Metformin doesn't provide cardiovascular benefits for people with diabetes.
While metformin didn't reduce the risk of atherosclerosis in people with type 1 diabetes as anticipated, secondary outcomes offered more promise, according to findings from the REMOVAL trial.
Levothyroxine Ineffective as treatment for Subclinical Hypothyroidism in seniors
Thyroid replacement therapy lowered thyrotropin levels in elderly patients, but treatment did not relieve any symptoms of hypothyroidism.
For poorly controlled diabetes, ertugliflozin may help control glucose.
Preliminary data for investigational ertugliflozin suggests favorable outcomes for people with recalcitrant type 2 diabetes despite improvements in physical activity and diet.
Thyroidectomy by a seasoned surgeon gives best outcome for Grave's disease
Total thyroidectomy is underutilized but promises the best outcomes for Grave's disease, but the risk of serious complications is high, necessitating referral to a highly trained surgeon.
Thyroid hormone levels may predict best diet for successful weight loss.
As regulators of metabolism, thyroid hormones help explain why some individuals lose weight while others don't on any given weight-loss regime.
Even in adults with normal thyroid function, these hormones play a role in body weight regulation and may help identify individuals more responsive to a dietary intervention aimed at promoting weight loss, and those who are deemed unresponsive may be better candidates for bariatric surgery.
Transgender Youth Benefit from Puberty Suppression
Clinical support for puberty suppression often improves emotional wellbeing during a time of sexual uncertainty and may ease feelings of gender incongruence.
Cannabis compound may have impact on diabetes.
Examining the effects of an endogenous cannabinoid uncovered a dual response in the pathways that regulate inflammatory response in the gut.
Aflibercept Injections preferred over laser surgery for treatment of Diabetic Re
Injections with a monoclonal antibody therapy, Eylea, provided superior results and outperformed laser surgery for treatment of diabetic retinopathy.
New bone-building agent, TYMLOS (abaloparatide) approved by FDA for older women
TYMLOS (abaloparatide), a new bone-building anabolic therapeutic agent for high fracture risk, older women, including those with diabetes or thyroid disease, gains Food and Drug Administration approval.
National Diabetes Prevention Program effective in reducing diabetes risk.
Participating in a structured lifestyle program with regularly attended sessions promotes improved eating habits and commitment to exercise forestallling diabetes risks.
Multimodal approach promises the best outcomes for Cushing's disease.
To achieve long-term remission, clinicians should anticipate the need for additional treatment following surgery for Cushing's disease in 25% of patients.
Diabetic Ketoacidosis Looks Like Type 2 Diabetes in African American.
In African Americans, men, and other minorities, ketosis-prone diabetes appears more consistent with type 2 diabetes but responds to insulin as if type 1 diabetes.