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Endocrine Research Updates

For Medical Professionals

Lipoprotein(a) suggests greater risk for inherited heart disease with diabetes.
From PROMIS, genetic variants that were exclusively associated with apoprotein(a) size and concentration provide further indication that lowering the lipoprotein(a) concentration may be a strategy to reduce cardiovascular disease risk.
Check for hypertension in individuals under age 40 with an endocrine disorder.
Evaluating patients with an endocrine-related disorder, particularly those under age 40 who present with high blood pressure, is critical to ensure treatment is provided to life-saving effect.
Dual Gene Mutations predict outcomes of aggressive thyroid cancer.
Papillary thyroid cancer is the most common form, and highly curable, but up to 20% of cases have a high rate of rapid growth and recurrence; genetic testing can improve their detection with greater chance for effective treatment.
Adding evolocumab to a statin reduces future heart attacks and lowers LDL .
Compelling data supports achieving a very low LDL-Cholesterol with combined statin-evolocumab therapy to reduce further risk of cardiovascular events, which presents important implications for people with diabetes.
Children with diabetes need early screening for diabetic retinopathy.
Among children with a diagnosis of diabetes, an estimated 1-in-4 cases of diabetic retinopathy may be going undetected for years, risking vision loss, based on current screening guidelines.
Choose medications that do not promote weight gain in people with obesity.
While diet, exercise, and behavior modification are key components of weight management, several physiological mechanisms act to preserve excess body weight, necessitating consideration of and conversations with the patient.
ADA promotes advances in treatment to prevent vision loss in people with diabete
Updated position statement from the American Diabetes Association highlights innovations in treatment, over the past 15 years, for people with diabetes who are most at risk for vision loss.
Assuring children avoid obesity requires a family-oriented, comprehensive approa
To most effectively reverse undesirable body weight in children, clinicians will need to employ a multifaceted approach of diet, physical activity, behavior modification, and education, involving the entire family.
Remote web-based screening improves screening for diabetes in children
Researchers sought to determine if the use of a computerized support system would allow for improved identification of pediatric patients at high risk for prediabetes and type 2 diabetes, and its implications to initiate earlier treatment.
Radioactive iodine preferred treatment for Graves' hyperthyroid disease.
Mayo Clinic Study found that RAI was favored over antithyroid medications and thyroidectomy, offering the best outcome for this most common form of hyperthyroid disease, among this group of patients.
Testosterone replacement offers little benefit for aging men.
EndocrineWeb highlights results of the last 2 of 7 studies—looking at the effects of testosterone replacement for anemia and bone strength in older men with low circulating hormone levels—from the National Institutes of Health (NIH) sponsored Testosterone Trials (TTrials).
No benefits found from testosterone supplementation in aging men.
Seeking confirmation of efficacy, results from 2 of the 4 testosterone trials (TTrials) are highlighted to address the growing practice of boosting low testosterone in men. This brief focuses on the findings of testosterone supplementation to achieve improved outcomes in Alzheimer’s disease and cardiovascular disease.
Identifying factors that may improve treatment for people with Graves' disease.
In an effort to tease out possible factors that might predict relapse, a team of researchers from the University of Buffalo conducted a meta-analysis of studies published over nearly 4 decades, encompassing more than 4000 patients treated for hyperthyroid disease.
Health outcomes improve when clinicians involve patients in treatment decisions
Individualizing care, rather than following guidelines and clinical recommendations uncritically, will improve disease management and reduce costs without compromising outcomes, according to researchers who evaluated current practice.
New ADA guidelines focus on prevention and screening for diabetic neuropathy.
Updated position statement issued by the American Diabetes Association for managing diabetic neuropathies focused on preventing and early screening as the primary goals.
Beyond genetics, DNA methylation is identified as a new factor in obesity
DNA methylation may join body mass index, adiposity, and gene expression as another factor that predisposes certain individuals to develop obesity, obesity-related conditions.
PES issues new guidelines to clarify when to treat children with short stature
Pediatric Endocrine Society offers updated recommendations for use of growth-promoting hormone therapy and related medications in children.
Combination therapy, not insulin, provides better long-term outcomes for T2D.
85% of patients with type 2 diabetes who received concurrent treatment with exenatide and pioglitazone achieved the ADA-recommended HBA1c goal of <7.0%, with fewer hypoglycemic incidents and less weight gain, achieving clinically improved outcomes over patients taking insulin.
Women can reduce chronic disease risks with regular strength training.
Women can reduce their risk of diabetes and other chronic conditions simply by incorporating resistance exercise into a weekly physical activity plan, according to the National Institute on Aging.
Metformin may alter gut micrflora, leading to improved glucose metabolism in T2D
Given the strength of the findings, people who take metformin for their diabetes appear to have an enriched gut microflora that fosters a more efficient response to glucose metabolism.
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