Endocrine Research Updates

For Medical Professionals

Higher Magnesium Intake May Lower Risk for Type 2 Diabetes
In a study involving more than 2,500 people, those with the highest magnesium intake had the lowest risk of developing type 2 diabetes over a 7-year period.
DPP-4 Inhibitor Onglyza (saxagliptin) Does Not Increase Heart Disease Risks
Large study shows no increased risk of myocardial infarction (heart attach), ischemic strokes, and death in over 16,000 patients treated with saxagliptin (Onglyza).
American Diabetes Association (ADA) New Guidelines Stress Individualized Meal Planning That Fits a Diabetics Food Preference and Lifestyle
Report stresses individualized meal planning that fits a person's food preferences and lifestyle.
Depressed patients have increased risk for diabetes
Antidepressants appeared to be associated with an increased risk for diabetes. However, it is unclear whether this is a causal relationship and the magnitude of the effect may be small.
woman getting ultrasound of a thyroid from doctor
List contains common tests to avoid as well as tests patients with diabetes really should be conducting.
The Endocrine Society and the American Association of Clinical Endocrinologists (AACE) released a list of specific tests or procedures that are commonly ordered but not always necessary in endocrinology.
Groups sought to standardize care
AACE, ACE, and TOS published clinical practice guidelines to teach healthy eating in order to prevent and manage endocrine and metabolic disorders.
Improvement in quality of care seen
Use of an outpatient electronic health record at Kaiser Permanente Northern California was associated with significant decreases in emergency department visits and hospitalizations among patients with diabetes.
Dysglycemia and peripheral neuropathy seen
Fluoroquinolones have been linked to increased risks of dysglycemia in patients with diabetes and peripheral neuropathy in diabetic and non-diabetes patients.
Greater psoriasis severity was associated with greater disease burden
Psoriasis is linked to a 22% increased risk for type 2 diabetes as well as a greater prevalence of other systemic comorbidities.
Weight loss reduces risk of developing type 2 diabetes by 85%
Patients who lose 10% of their body weight within 6 months of diagnosis of pre-diabetes may reduce their risk of developing type 2 diabetes by 85% over the next 3 years.
Twenty-five percent decreased risk for cancer-related deaths seen

Cumulative exposure to metformin after prostate cancer diagnosis was linked to a nearly 25% decreased risk for cancer-related mortality in men with diabetes.

Microvascular disease in the kidney is paralleled by microvascular disease in the brain

Cognitive decline in patients with diabetes may be associated with microvascular changes in the kidneys, leading to microvascular changes in the brain, a new research study suggests.

Diabetic foot ulcers debridement should be part of the standard of care, and repetitive weekly debridement may be beneficial

Frequent debridement of chronic wounds is associated with improved healing, according to James Wilcox, RN, lead author of a retrospective study of more than 300,000 wounds.

Patients with type 2 diabetes who are taking glucose-lowering medications are at risk for severe hypoglycemia regardless of whether their diabetes is poorly or well controlled

Patients with type 2 diabetes who are taking glucose-lowering medications are at risk for severe hypoglycemia regardless of whether their diabetes is poorly or well controlled, according to data fr

Insufficient evidence of cancer link seen
There is currently insufficient evidence to support a definitive link between antihyperglycemic medications and cancer development, according to a consensus statement released by the American Association of Clinical Endocrinologists (AACE).
Weight loss, exercise, and some supplements can help lower inflammation, reducing risks of heart disease, cancer and diabetes

Many patients with diabetes take complementary and alternative (CAM) therapies—some to lessen the number of diabetes agents they need and others to treat comorbidities such as peripheral neuropathy

Taskforce finds current screening recommendations missed detecting more than 50% of diabetes cases
The US Preventive Services Task Force (USPSTF) screening recommendations missed detecting more than 50% of cases of undiagnosed diabetes.
Counseling calls covered medication adherence strategies, healthy eating, increasing physical activity, stress management, and the importance of patient-physician discussion

Telephone counseling provided by health educators may help people with diabetes lower their A1c levels, according to data from the Bronx A1c Telephonic Behavioral Intervention

New study suggests that eating two large meals per day improves insulin sensitivity and promotes weight loss better in patients with type 2 diabetes than grazing

Conventional dietary wisdom holds that eating frequent but small meals—“grazing”—helps to maintain steady blood glucose and promotes weight loss.

image of the human body and organs like the stomach and pancreas
FDA review finds no link between incretin therapies and the development of pancreatic disease among patients with diabetes

Commentary by Robert E. Ratner, MD and J. Michael Gonzalez-Campoy, MD, PhD, FACE