Endocrine Research Updates

For Medical Professionals

Twenty-five percent decreased risk for cancer-related deaths seen

Cumulative exposure to metformin after prostate cancer diagnosis was linked to a nearly 25% decreased risk for cancer-related mortality in men with diabetes.

Microvascular disease in the kidney is paralleled by microvascular disease in the brain

Cognitive decline in patients with diabetes may be associated with microvascular changes in the kidneys, leading to microvascular changes in the brain, a new research study suggests.

Diabetic foot ulcers debridement should be part of the standard of care, and repetitive weekly debridement may be beneficial

Frequent debridement of chronic wounds is associated with improved healing, according to James Wilcox, RN, lead author of a retrospective study of more than 300,000 wounds.

Patients with type 2 diabetes who are taking glucose-lowering medications are at risk for severe hypoglycemia regardless of whether their diabetes is poorly or well controlled

Patients with type 2 diabetes who are taking glucose-lowering medications are at risk for severe hypoglycemia regardless of whether their diabetes is poorly or well controlled, according to data fr

Insufficient evidence of cancer link seen
There is currently insufficient evidence to support a definitive link between antihyperglycemic medications and cancer development, according to a consensus statement released by the American Association of Clinical Endocrinologists (AACE).
Weight loss, exercise, and some supplements can help lower inflammation, reducing risks of heart disease, cancer and diabetes

Many patients with diabetes take complementary and alternative (CAM) therapies—some to lessen the number of diabetes agents they need and others to treat comorbidities such as peripheral neuropathy

Taskforce finds current screening recommendations missed detecting more than 50% of diabetes cases
The US Preventive Services Task Force (USPSTF) screening recommendations missed detecting more than 50% of cases of undiagnosed diabetes.
Counseling calls covered medication adherence strategies, healthy eating, increasing physical activity, stress management, and the importance of patient-physician discussion

Telephone counseling provided by health educators may help people with diabetes lower their A1c levels, according to data from the Bronx A1c Telephonic Behavioral Intervention

New study suggests that eating two large meals per day improves insulin sensitivity and promotes weight loss better in patients with type 2 diabetes than grazing

Conventional dietary wisdom holds that eating frequent but small meals—“grazing”—helps to maintain steady blood glucose and promotes weight loss.

image of the human body and organs like the stomach and pancreas
FDA review finds no link between incretin therapies and the development of pancreatic disease among patients with diabetes

Commentary by Robert E. Ratner, MD and J. Michael Gonzalez-Campoy, MD, PhD, FACE

Greater than 40% of Alzheimer's patients had undiagnosed pre-diabetes

When researchers began enrolling patients with Alzheimer’s disease (AD) into a trial of a dementia medication, they found that more than 40% of patients had undiagnosed impaired glucose toler

Angioplasty performed with drug-eluting balloons lead to lower restenosis rates

In diabetic patients with below-the-knee critical limb ischemia, use of a drug-eluting balloon (DEB) for angioplasty lead to markedly lower restenosis rates at 1 year compared to conventional angio

Weight-loss (bariatric) surgery was found to be more effective than diet and exercise at controlling blood glucose for overweight patients with diabetes

Bariatric surgery was found to be more effective than nonsurgical interventions at controlling blood glucose for patients with diabetes at the low end of the obesity spectrum (body mass index [BMI]

Two-Thirds of Patients Do Not Bring Glucose Meters to Office Visits

Less than one-third of patients with diabetes in a recent retrospective study brought their glucose meters to office visits.

Chronic low-grade inflammation found in many patients with diabetes

Salsalate, a generic non-steroidal anti-inflammatory drug (NSAID) used to treat arthritis, significantly lowered blood glucose levels and decreased inflammatory mediators in patients with type 2 di

High emotional toll seen in both patients and families

Study examines high toll the disease takes on patients and families, as well as disconnect between patient and doctor perceptions of quality of life issues.

In the Short-Term, Weight-loss (Bariatric) Surgery Improves Diabetes Goals Better Than Lifestyle Changes

In mild to moderately obese patients with diabetes, the use of bariatric surgery is more likely to meet established diabetes goals in the short-term than lifestyle-medical management alone, but wit

New screening tools for metabolic syndrome may better identify patients at risk for diabetes and heart disease
A new sex- and ethnicity-specific tool for assessing the risk for metabolic syndrome may better identify people at highest risk for developing type 2 diabetes
Aggressive blood glucose management does not reduce mortality or incidence of infection

The risks of aggressively lowering blood glucose levels to near normal in critically ill patients with or without diabetes may not outweigh the benefits, according to new guidelines from the Americ

Children and teenagers with type 2 diabetes are at high risk of developing heart and kidney disease

Children and teenagers with type 2 diabetes are at high risk for developing early and rapidly progressing signs of risk for heart disease and kidney disease, as well as faster deterioration of &bet