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Endocrine Research Updates

For Medical Professionals

Estrogen molecule pictured
Estrogen may suppress the urge for binge eating by activating serotonin neurons in the dorsal raphe nuclei—where binge eating behaviors are believed to be regulated—according to an animal study in the August 25 Journal of Clinical Investigation.
woman holding one pill in between her thumb and index finger
The U.S. Food and Drug Administration has approved a fixed-dose therapy combining the sodium glucose co-transporter 2 inhibitor canagliflozin and metformin hydrochloride in a single tablet for the treatment of adults with type 2 diabetes.
diverse group of people
An estimated 40% of adults in the United States will develop diabetes in their lifetime, with even higher risks found in Hispanic men and women and non-Hispanic black women, according to data from the Centers from Disease Control and Prevention.
Face to face interview
EndocrineWeb spoke with Dr. Richard Kloos about the incidence of thyroid nodules and the role of gene expression classifiers. The interview was timely considering that during The Endocrine Society’s annual meeting the American Thyroid Association’s (ATA) preliminary guidelines regarding the management of thyroid nodules were announced.
hormones word cloud
Patients who have Cushing’s disease and receive mifepristone must undergo surveillance for evidence of tumor progression.
Thyroid testing tube
Serum thyroid stimulating hormone autoantibodies (TSAbs) levels are sensitive and specific biomarkers for the diagnosis of Graves’ disease in childhood.
pregnant woman looking on a laptop computer
Research suggests that women diagnosed with differentiated thyroid cancer during pregnancy or soon after are at significantly increased risk for tumor persistence or recurrence compared to women diagnosed when they are not pregnant.
Gastric Bypass for Weight Loss - You Are Actually Re-routing Your Stomach in Ord
Commentary by J. Michael Gonzalez-Campoy, MD, PhD, FACE
The concept of offering bariatric surgery at a BMI lower than 35 has emerged as a viable option for individuals at high risk. As emerging data on safety and long-term efficacy emerges for bariatric surgery in this patient population.
woman getting ultrasound of a thyroid from doctor
Despite the increasing rates, the death rate from thyroid cancer has remained stable at 0.5 deaths per 100,000 people. The authors suggested that the increasing rates of thyroid cancer may be due to an increase in the detection of subclinical papillary thyroid cancers, which are unlikely to affect patients’ overall health.
calendar
The U.S. Food and Drug Administration has approved a third glucagon-like peptide-1 (GLP-1) receptor antagonist—albiglutide—for use as an adjunct to diet and exercise in the treatment of type 2 diabetes.
feet on a scale
Lower mortality and co-morbid outcomes were found following weight loss achieved following gastric bypass surgery for morbid obesity.
A review of bariatric surgery studies published between 2003 and 2012—the most recent review of its kind—confirms that bariatric surgery provides “substantial and sustained effects on weight loss and ameliorates obesity-attributable comorbidities in the majority of bariatric patients.
diabetic young woman holding glucometer, standing in front of mirror
Many pediatricians and family practice physicians recently surveyed were unaware that hemoglobin A1c is a recommended diagnostic test for type 2 diabetes; however, education on this recommendation was linked an increased number of physicians who said they would use the test in a hypothetical case involving an adolescent, according to a cross-sectional study in the February Journal of Adolescent Health.
overweight young woman looking on a laptop computer
Bariatric surgery is increasingly being used to treat adolescents with severe obesity, despite limited data regarding the safety of these procedures in this age group. Now, the largest study on this topic shows that most teenagers that underwent bariatric surgery for weight loss had few short-term complications, as reported in "JAMA Pediatrics."
Hand writing diabetes healthcare content with blue marker on virtual whiteboard
Inpatient diabetes education was associated with 34% reduced risk of all-cause readmissions within 30 days, and 20% reduced risk of readmissions at 180 days, after adjustment for other potentially confounding variables, in a retrospective study published in Diabetes Care.
Woman with pills in her hand
Sulfonylureas are as effective as dipeptidyl peptidase-4 (DDP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists as second-line treatments for type 2 diabetes but at a lower cost, according to a study in February 26 issue of Diabetes Care.
Pregnant woman having her blood sugar tested
Gestational diabetes appeared as an independent risk factor for heart disease whether or not the women went on to develop diabetes or metabolic syndrome.
“Concern regarding potential cardiovascular adverse events associated with testosterone use was raised in 2010 when a signal was noted in a randomized clinical trial in progress, leading to the premature termination of the study,” commented Tamara L. Wexler, MD, PhD. “Two recent large retrospective observational trials suggest there is a risk for some cardiovascular events in certain populations, prompting The Endocrine Society statement,” she said.
Heart failure - diagnosis written on a white piece of paper. Syringe and vaccine
The U.S. Food and Drug Administration (FDA) announced that it will evaluate clinical trial data from the manufacturer of saxagliptin (Onglyza and Kombiglyze XR) to investigate whether this medication is linked to an increased risk of heart failure.
Depressed woman looking at food
Depression and impulse control disorders (eating disorders in particular) are independently associated with diagnosis of type 2 diabetes, according to a cross-sectional survey of adults published online ahead of print in Diabetologia.
Pharmacy background, focus on person typing on cash register
After being off the marked for over a year, the branded medication Levoxyl (levothyroxine sodium) is expected to be available in pharmacies on approximately March 3, 2014, according to a statement released by Pfizer. The medication is approved to treat hypothyroidism and various types of euthyroid goiters.
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