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Endocrine Research Updates

For Medical Professionals

pregnant woman reading on her laptop
Hyperthyroidism and high-normal free T4 levels in pregnancy are associated with an increased risk for pregnancy-induced hypertension and preeclampsia, according to findings from a population-based cohort study. The study was published online ahead of print in the Journal of Clinical Endocrinology and Metabolism.
Diabetes education
The U.S. Preventive Services Task Force (USPSTF) has issued a draft recommendation regarding screening for abnormal blood glucose levels in all adults at increased risk for type 2 diabetes.
Colorful cogs in the brain depicting mental function
Weight loss from bariatric surgery appears to reverse the increased cerebral metabolism and poor executive function associated with obesity, according to a study reported in the August 26 Journal of Clinical Endocrinology and Metabolism.
womans feet on a acale with an apple and a tape measure
Members of the Endocrinologic and Metabolic Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) voted 14-1 in favor of approving the once-daily human GLP-1 analogue liraglutide for the treatment of obesity.
overweight woman holding fruit and vegetables
The U.S. Food and Drug Administration (FDA) has approved the combination agent naltrexone/bupropion (Contrave) extended release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults who are obese (BMI ≥ 30 kg/m2) or overweight (27 kg/m2) and have at least one weight-related comorbidity, including hyperension, type 2 diabetes, and dyslipidemia.
Insulin dripping from the end of an injection pen
Dulaglutide (Trulicity), a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist, is now approved as an adjunct to diet and exercise in the treatment of type 2 diabetes in adults.
Type 1 Diabetes being handwritten in red on screen
The U.S. Food and Drug Administration (FDA) approved for marketing the first zinc transporter 8 autoantibody (ZnT8Ab) test to aid in the diagnosis of type 1 diabetes.
Estrogen molecule pictured
Estrogen may suppress the urge for binge eating by activating serotonin neurons in the dorsal raphe nuclei—where binge eating behaviors are believed to be regulated—according to an animal study in the August 25 Journal of Clinical Investigation.
woman holding one pill in between her thumb and index finger
The U.S. Food and Drug Administration has approved a fixed-dose therapy combining the sodium glucose co-transporter 2 inhibitor canagliflozin and metformin hydrochloride in a single tablet for the treatment of adults with type 2 diabetes.
diverse group of people
An estimated 40% of adults in the United States will develop diabetes in their lifetime, with even higher risks found in Hispanic men and women and non-Hispanic black women, according to data from the Centers from Disease Control and Prevention.
Face to face interview
EndocrineWeb spoke with Dr. Richard Kloos about the incidence of thyroid nodules and the role of gene expression classifiers. The interview was timely considering that during The Endocrine Society’s annual meeting the American Thyroid Association’s (ATA) preliminary guidelines regarding the management of thyroid nodules were announced.
hormones word cloud
Patients who have Cushing’s disease and receive mifepristone must undergo surveillance for evidence of tumor progression.
Thyroid testing tube
Serum thyroid stimulating hormone autoantibodies (TSAbs) levels are sensitive and specific biomarkers for the diagnosis of Graves’ disease in childhood.
pregnant woman looking on a laptop computer
Research suggests that women diagnosed with differentiated thyroid cancer during pregnancy or soon after are at significantly increased risk for tumor persistence or recurrence compared to women diagnosed when they are not pregnant.
Gastric Bypass for Weight Loss - You Are Actually Re-routing Your Stomach in Ord
Commentary by J. Michael Gonzalez-Campoy, MD, PhD, FACE
The concept of offering bariatric surgery at a BMI lower than 35 has emerged as a viable option for individuals at high risk. As emerging data on safety and long-term efficacy emerges for bariatric surgery in this patient population.
woman getting ultrasound of a thyroid from doctor
Despite the increasing rates, the death rate from thyroid cancer has remained stable at 0.5 deaths per 100,000 people. The authors suggested that the increasing rates of thyroid cancer may be due to an increase in the detection of subclinical papillary thyroid cancers, which are unlikely to affect patients’ overall health.
calendar
The U.S. Food and Drug Administration has approved a third glucagon-like peptide-1 (GLP-1) receptor antagonist—albiglutide—for use as an adjunct to diet and exercise in the treatment of type 2 diabetes.
feet on a scale
Lower mortality and co-morbid outcomes were found following weight loss achieved following gastric bypass surgery for morbid obesity.
A review of bariatric surgery studies published between 2003 and 2012—the most recent review of its kind—confirms that bariatric surgery provides “substantial and sustained effects on weight loss and ameliorates obesity-attributable comorbidities in the majority of bariatric patients.
diabetic young woman holding glucometer, standing in front of mirror
Many pediatricians and family practice physicians recently surveyed were unaware that hemoglobin A1c is a recommended diagnostic test for type 2 diabetes; however, education on this recommendation was linked an increased number of physicians who said they would use the test in a hypothetical case involving an adolescent, according to a cross-sectional study in the February Journal of Adolescent Health.
overweight young woman looking on a laptop computer
Bariatric surgery is increasingly being used to treat adolescents with severe obesity, despite limited data regarding the safety of these procedures in this age group. Now, the largest study on this topic shows that most teenagers that underwent bariatric surgery for weight loss had few short-term complications, as reported in "JAMA Pediatrics."
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