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Endocrine Research Updates

For Medical Professionals

Pharmacist and customer looking at medication box
Diabetes complications
CDC Survey Shows Age-Related Variability in Diabetes Management
Younger adults with diabetes (age 18 to 39 years) are less likely than older patients to take medication to control their glucose levels or to see a doctor biannually.
pituitary
Acromegaly
Octreotide Capsules Found Safe and Effective for Acromegaly in Phase 3 Study
An investigational oral formulation of octreotide was found to be safe and effective in the treatment of acromegaly in a phase 3 open-label study published online ahead of print in the Journal of Clinical Endocrinology & Metabolism.
Young woman looking in the refrigerator at late evening
Obesity
Vyvanse® Approved For Binge-Eating Disorder
The U.S. Food and Drug Administration (FDA) expanded the approved uses of Vyvanse® (lisdexamfetamine dimesylate) to include treatment of moderate-to-severe binge-eating disorder in adults, making it the first medication approved to treat this condition.
Brain outline in red pencil
Diabetes complications
Marked Cognitive and Memory Decline in People Who Develop Diabetes in Mid-life
People who develop diabetes in middle-age are more likely to experience significant memory and cognitive problems over the next 20 years compared to people without diabetes in midlife, according to a prospective cohort study.
Pancreatic islet cell normal and type 1 diabetic
Type 1 Diabetes
Cell Replacement Therapies Show Promise in the Treatment of Type 1 Diabetes
Researchers discussed the latest advances in cell replacement therapy for the treatment of type 1 diabetes in the January issue of Endocrinology.
Glucometer pictured as part of glucose management
Type 1 Diabetes
Early Intensive Treatment Linked to Lower Risk of Death in Type 1 Diabetes
The findings of this important paper emphasize one specific word: early. It is important to treat these patients with type 1 aggressively and early, when they are either adolescent or young adults, or as soon as they are diagnosed if they are diagnosed in their 20s.
Cropped image of male doctor with prescription medicine bottle in clinic
Type 2 Diabetes
Glyxambi Approved as First Dual SGLT2 and DDP-4 Inhibitor for Type 2 Diabetes
Glyxambi is now approved as an adjunct to nutrition and physical activity for the treatment of adults with type 2 diabetes mellitus. Glyxambi, from Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company, is the first diabetes treatment in the United States to combine the dual mechanisms of action of a sodium glucose co-transporter-2 (SGLT2) inhibitor and a dipeptidyl peptidase-4 (DPP-4) inhibitor.
woman with smart phone, resting after gym workout
Type 2 Diabetes
Up to 20% of Patients with Type 2 Diabetes May be Exercise Resistant
Studies suggest that up to 20% of people with type 2 diabetes may be exercise resistant—meaning that they do not see any improvement in glucose level when following a supervised exercise regimen, according to a systematic review.
Type 1 Diabetes
Researchers Convert Stem Cells Into Insulin-Producing Cells
Researchers have developed a multistep protocol that converts human embryonic stem cells into insulin-producing cells that can reverse diabetes in approximately 40 days in an animal model—much faster than the 4 months required for cells produced with previous methods. The goal is to be able transplant these insulin-producing cells for the treatment of type 1 diabetes, researchers reported in a study published in the November issue of Nature Biotechnology.
highlight on legs and feet
Diabetes complications
Spinal Cord Stimulation Shows Greater Efficacy than Best Medical Treatment in Reducing Diabetic Peripheral Neuropathy Pain
Spinal cord stimulation (SCS) reduced pain more effectively than optimal medical treatment in a study of patients with moderate to severe diabetic peripheral neuropathy in their lower limbs, as reported in the November issue of Diabetes Care. Spinal cord stimulation is not without risks, as one treatment-related fatality was reported in this study.
older man using a glucometer
Type 2 Diabetes
Glycemic Control Indirectly Improved in Patients with Diabetes and Lumbar Spinal Stenosis Following Decompression Surgery
According to a prospective cohort study published online ahead of print in The Spine Journal, patients with type 2 diabetes had significant reductions in A1C levels following decompression spine surgery to treat lumbar spinal stenosis.
Doctor holding a biopsy syringe
Thyroid cancer
Repeat Fine-Needle Aspiration Detects Thyroid Cancer in Less than 1% Cases
Repeat fine-needle aspiration following a nondiagnostic result detected malignancy in less than 1% of cases, according to findings reported in the September issue of Radiology. The authors suggest that ultrasound followup may be more appropriate than repeat fine-needle aspiration in patients with initially nondiagnostic results from thyroid nodule biopsy.
Illustration of thyroid gland and nodule
Thyroid cancer
Autoimmune Thyroiditis Not Linked to Increased Risk for Differentiated Thyroid Cancer
A link between autoimmune thyroiditis and differentiated thyroid cancer was found in a surgical series of patients undergoing thyroidectomy but not in a cytological series of patients who underwent fine-needle aspiration, according to findings from a retrospective study published in the September issue of the Journal of Clinical Endocrinology and Metabolism.
pregnant woman reading on her laptop
Hyperthyroidism
Hyperthyroidism, T4 Levels Linked to Hypertension in Pregnancy
Hyperthyroidism and high-normal free T4 levels in pregnancy are associated with an increased risk for pregnancy-induced hypertension and preeclampsia, according to findings from a population-based cohort study. The study was published online ahead of print in the Journal of Clinical Endocrinology and Metabolism.
Diabetes education
Type 2 Diabetes
U.S. Preventive Services Task Force Issues Draft Recommendation Statement on Screening for Type 2 Diabetes
The U.S. Preventive Services Task Force (USPSTF) has issued a draft recommendation regarding screening for abnormal blood glucose levels in all adults at increased risk for type 2 diabetes.
Colorful cogs in the brain depicting mental function
Obesity
Bariatric Surgery Improves Cognitive Function in Obese Women
Weight loss from bariatric surgery appears to reverse the increased cerebral metabolism and poor executive function associated with obesity, according to a study reported in the August 26 Journal of Clinical Endocrinology and Metabolism.
womans feet on a acale with an apple and a tape measure
Obesity
FDA Advisory Committee Votes in Favor of Liraglutide Approval for Obesity
Members of the Endocrinologic and Metabolic Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) voted 14-1 in favor of approving the once-daily human GLP-1 analogue liraglutide for the treatment of obesity.
overweight woman holding fruit and vegetables
Obesity
Naltrexone/Bupropion Approved for Chronic Weight Management
The U.S. Food and Drug Administration (FDA) has approved the combination agent naltrexone/bupropion (Contrave) extended release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults who are obese (BMI ≥ 30 kg/m2) or overweight (27 kg/m2) and have at least one weight-related comorbidity, including hyperension, type 2 diabetes, and dyslipidemia.
Insulin dripping from the end of an injection pen
Type 2 Diabetes
FDA Approves Once-Weekly GLP-1 Agonist for Type 2 Diabetes
Dulaglutide (Trulicity), a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist, is now approved as an adjunct to diet and exercise in the treatment of type 2 diabetes in adults.
Type 1 Diabetes being handwritten in red on screen
Type 1 Diabetes
FDA Approves Marketing of First ZnT8Ab Autoantibody Assay for Type 1 Diabetes Diagnosis
The U.S. Food and Drug Administration (FDA) approved for marketing the first zinc transporter 8 autoantibody (ZnT8Ab) test to aid in the diagnosis of type 1 diabetes.
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