Endocrine Research Updates

For Medical Professionals

Cropped image of male doctor with prescription medicine bottle in clinic
Glyxambi is now approved as an adjunct to nutrition and physical activity for the treatment of adults with type 2 diabetes mellitus. Glyxambi, from Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company, is the first diabetes treatment in the United States to combine the dual mechanisms of action of a sodium glucose co-transporter-2 (SGLT2) inhibitor and a dipeptidyl peptidase-4 (DPP-4) inhibitor.
woman with smart phone, resting after gym workout
Studies suggest that up to 20% of people with type 2 diabetes may be exercise resistant—meaning that they do not see any improvement in glucose level when following a supervised exercise regimen, according to a systematic review.
Researchers have developed a multistep protocol that converts human embryonic stem cells into insulin-producing cells that can reverse diabetes in approximately 40 days in an animal model—much faster than the 4 months required for cells produced with previous methods. The goal is to be able transplant these insulin-producing cells for the treatment of type 1 diabetes, researchers reported in a study published in the November issue of Nature Biotechnology.
highlight on legs and feet
Spinal cord stimulation (SCS) reduced pain more effectively than optimal medical treatment in a study of patients with moderate to severe diabetic peripheral neuropathy in their lower limbs, as reported in the November issue of Diabetes Care. Spinal cord stimulation is not without risks, as one treatment-related fatality was reported in this study.
older man using a glucometer
According to a prospective cohort study published online ahead of print in The Spine Journal, patients with type 2 diabetes had significant reductions in A1C levels following decompression spine surgery to treat lumbar spinal stenosis.
Doctor holding a biopsy syringe
Repeat fine-needle aspiration following a nondiagnostic result detected malignancy in less than 1% of cases, according to findings reported in the September issue of Radiology. The authors suggest that ultrasound followup may be more appropriate than repeat fine-needle aspiration in patients with initially nondiagnostic results from thyroid nodule biopsy.
Illustration of thyroid gland and nodule
A link between autoimmune thyroiditis and differentiated thyroid cancer was found in a surgical series of patients undergoing thyroidectomy but not in a cytological series of patients who underwent fine-needle aspiration, according to findings from a retrospective study published in the September issue of the Journal of Clinical Endocrinology and Metabolism.
pregnant woman reading on her laptop
Hyperthyroidism and high-normal free T4 levels in pregnancy are associated with an increased risk for pregnancy-induced hypertension and preeclampsia, according to findings from a population-based cohort study. The study was published online ahead of print in the Journal of Clinical Endocrinology and Metabolism.
Diabetes education
The U.S. Preventive Services Task Force (USPSTF) has issued a draft recommendation regarding screening for abnormal blood glucose levels in all adults at increased risk for type 2 diabetes.
Colorful cogs in the brain depicting mental function
Weight loss from bariatric surgery appears to reverse the increased cerebral metabolism and poor executive function associated with obesity, according to a study reported in the August 26 Journal of Clinical Endocrinology and Metabolism.
womans feet on a acale with an apple and a tape measure
Members of the Endocrinologic and Metabolic Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) voted 14-1 in favor of approving the once-daily human GLP-1 analogue liraglutide for the treatment of obesity.
overweight woman holding fruit and vegetables
The U.S. Food and Drug Administration (FDA) has approved the combination agent naltrexone/bupropion (Contrave) extended release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults who are obese (BMI ≥ 30 kg/m2) or overweight (27 kg/m2) and have at least one weight-related comorbidity, including hyperension, type 2 diabetes, and dyslipidemia.
Insulin dripping from the end of an injection pen
Dulaglutide (Trulicity), a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist, is now approved as an adjunct to diet and exercise in the treatment of type 2 diabetes in adults.
Type 1 Diabetes being handwritten in red on screen
The U.S. Food and Drug Administration (FDA) approved for marketing the first zinc transporter 8 autoantibody (ZnT8Ab) test to aid in the diagnosis of type 1 diabetes.
Estrogen molecule pictured
Estrogen may suppress the urge for binge eating by activating serotonin neurons in the dorsal raphe nuclei—where binge eating behaviors are believed to be regulated—according to an animal study in the August 25 Journal of Clinical Investigation.
woman holding one pill in between her thumb and index finger
The U.S. Food and Drug Administration has approved a fixed-dose therapy combining the sodium glucose co-transporter 2 inhibitor canagliflozin and metformin hydrochloride in a single tablet for the treatment of adults with type 2 diabetes.
diverse group of people
An estimated 40% of adults in the United States will develop diabetes in their lifetime, with even higher risks found in Hispanic men and women and non-Hispanic black women, according to data from the Centers from Disease Control and Prevention.
Face to face interview
EndocrineWeb spoke with Dr. Richard Kloos about the incidence of thyroid nodules and the role of gene expression classifiers. The interview was timely considering that during The Endocrine Society’s annual meeting the American Thyroid Association’s (ATA) preliminary guidelines regarding the management of thyroid nodules were announced.
hormones word cloud
Patients who have Cushing’s disease and receive mifepristone must undergo surveillance for evidence of tumor progression.
Thyroid testing tube
Serum thyroid stimulating hormone autoantibodies (TSAbs) levels are sensitive and specific biomarkers for the diagnosis of Graves’ disease in childhood.