Endocrine Research Updates

For Medical Professionals

man in front of refrigerator
Healthy men fed approximately 6,000 calories per day for 1 week experienced rapid weight gain as well as systemic and adipose tissue insulin resistance and oxidative stress, demonstrating for the first time in vivo a direct relationship between excessive nutrient intake and the development of insulin resistance.
Child's Hand on Adult Hand
A Q&A with A. Jay Cohen, MD
EndocrineWeb provides a Q&A with A. Jay Cohen, MD summarizing his presentation made during AACE in May 2015. Here he discusses the challenges that arise during the transition from adolescent to adult care among patients with endocrine disorders.
Elderly Woman Reading Warning Labels on Pill Bottles
The FDA has strengthened the warning regarding an increased risk for bone fractures and decreased bone mineral density for the type 2 diabetes medication canagliflozin (Invokana, Invokamet), and added a new item to Warnings and Precautions section and revised the Adverse Reactions section of the prescribing information.
cross section of a human kidney
While impaired renal function is considered a barrier to use of bisphosphonates, the researchers found that measures of renal function remained stable or improved slightly following use of pamidronate.
boy eating apple
A minority of adults and caregivers of children with type 1 diabetes routinely download and review data from diabetes devices, according to data from a cross-sectional survey published in Diabetes Technology and Therapeutics.
pituitary-thyroidal axis
Conflicting data have led to uncertainly regarding the association between mild thyroid failure and cognitive function. In the first-ever systematic review and meta-analysis, researchers found a possible link between subclinical hypothyroidism and cognitive impairment in individuals younger than 75 years of age and in those with higher thyroid stimulating hormone levels. James V. Hennessey, MD provides insightful commentary.
dumb bells, measuring tape, water bottle, medication for weight management
Liraglutide 3.0 mg once daily as an adjunct to a reduced-calorie meal plan and physical activity was associated with clinically meaningful and sustained weight loss in a 56-week, randomized, double-blind trial involving more than 3,700 patients who were overweight or obese.
Human stomach
A new balloon device to treat obesity without the need for invasive surgery was approved by the U.S. Food and Drug Administration (FDA). The ReShape Integrated Dual Balloon System works by occupying space in the stomach, which limits the space for food intake and triggers feelings of fullness.
Professional female singer, vocalist
In the first study of its kind, researchers found that all 27 consecutive professional voice users (including professional operatic performers) who underwent neural monitored thyroid surgery were able to return to performance, researchers reported in a recent issue of Thyroid.
GLP-1 receptor agonist, liraglutide, promotes weight loss and bone health.
Treating for type 2 diabetes, the GLP-1 receptor agonist, Liraglutide, promotes weight loss in post-menopausal women and preserves bone health.
New findings suggest that the GLP-1 receptor agonist liraglutide may prevent osteoporosis when used for chronic weight management in post-menopausal women with type 2 diabetes..
People with type 1 diabetes are at increased risk for celiac disease (CD), particularly in the early course of diabetes, according to findings from a systematic review of the literature.
Psychologist giving patient support
Most information and support needs among survivors of thyroid cancer are unmet, according to a large online survey reported in the June issue of Thyroid. Key opinion leaders comment on the Morley-Goldfarb study.
Words related to blood sugar
Exposure to urinary metabolites of the phthalate compound di-isononyl phthalate (DINP), which is increasingly used in the manufacturing of consumer products, was linked to an increased risk of high diabetes in adolescents enrolled in a cross-sectional analysis reported in the Journal of Clinical Endocrinology and Metabolism.
Nutritional labels
Mealtime insulin dosing calculation should focus on meal composition—including fat, protein, and glycemic index—rather than carbohydrate counting alone, according to a systematic review published in the June issue of Diabetes Care.
Vials for samples for lab testing
Unreliable estrogen measurements negatively impact the treatment of and research into many hormone-related cancers and chronic conditions. To improve patient care, a panel of medical experts has called for accurate, standardized estrogen testing methods in a statement published in the Journal of Clinical Endocrinology & Metabolism.
Liver disease
Commentary by Paola Portillo-Sanchez, MD, and Discussion by Giovanni Targher, MD
Nonalcoholic fatty liver disease (NAFLD) was found in 50% of patients with type 2 diabetes who had normal aminotransferase levels in a recent study reported in the June issue of the Journal of Clinical Endocrinology & Metabolism.
Hispanic student getting off schoolbus
Don McLeod, MD, MPH, PhD, and Terry F. Davies, MD, Comment
Non-Hispanic blacks have a nearly 3-fold higher prevalence of thyrotoxicosis than non-Hispanic whites, according to analysis of data from National Health and Nutritional Examination Surveys (NHANES) reported in the June issue of Thyroid.
Regular dental appointment on calendar
Robert J. Genco, DDS, PhD, and Courtney Kloberdanz, DDS, Comment
Screening for diabetes during regular dental visits led to the diagnosis of diabetes and prediabetes in 12.3% and 23.3% of 1,022 patients enrolled in a recent study published in the Journal of the American Dental Association.
Medical education resources
Ethan Lazarus, MD, Comments
While obesity is an epidemic in the United States, many physicians receive little training on obesity treatment during medical school. Read this article to find out how the American Medical Association and American Society of Bariatric Physicians are working together to resolve this problem.
illustration of a hip fracture highlighted in red
Subclinical hyperthyroidism was associated with an increased risk of hip fracture and other fractures in an observational study involving data from more than 70,000 participants.