Endocrine Research Updates

For Medical Professionals

Link Between Excessive Calorie Intake and Development of Insulin Resistance Found

Healthy men fed approximately 6,000 calories per day for 1 week experienced rapid weight gain as well as systemic and adipose tissue insulin resistance and oxidative stress, demonstrating for the first time in vivo a direct relationship between excessive nutrient intake and the development of insulin resistance.

Other Endocrine Disorders

Transitioning Care from Adolescence to Adulthood in Patients with Endocrine Disorders

A Q&A with A. Jay Cohen, MD

EndocrineWeb provides a Q&A with A. Jay Cohen, MD summarizing his presentation made during AACE in May 2015. Here he discusses the challenges that arise during the transition from adolescent to adult care among patients with endocrine disorders.

Elderly Woman Reading Warning Labels on Pill Bottles

Other Endocrine Disorders

FDA Strengthens Warnings on Bone Fracture Risk With Canagliflozin (Invokana, Invokamet)

The FDA has strengthened the warning regarding an increased risk for bone fractures and decreased bone mineral density for the type 2 diabetes medication canagliflozin (Invokana, Invokamet), and added a new item to Warnings and Precautions section and revised the Adverse Reactions section of the prescribing information.

Other Endocrine Disorders

Pamidronate Linked to Greater Likelihood for Survival, Ventilator Liberation in Chronic Critical Illness

While impaired renal function is considered a barrier to use of bisphosphonates, the researchers found that measures of renal function remained stable or improved slightly following use of pamidronate.

Type 1 Diabetes

Few Patients with Type 1 Diabetes Routinely Review Data from Diabetes Devices

A minority of adults and caregivers of children with type 1 diabetes routinely download and review data from diabetes devices, according to data from a cross-sectional survey published in Diabetes Technology and Therapeutics.

Hypothyroidism

Subclinical Hypothyroidism May be Linked to Cognitive Impairment in Patients Younger Than Age 75

Conflicting data have led to uncertainly regarding the association between mild thyroid failure and cognitive function. In the first-ever systematic review and meta-analysis, researchers found a possible link between subclinical hypothyroidism and cognitive impairment in individuals younger than 75 years of age and in those with higher thyroid stimulating hormone levels. James V. Hennessey, MD provides insightful commentary.

dumb bells, measuring tape, water bottle, medication for weight management

Obesity

Efficacy of Liraglutide in Lowering Body Weight Shown in Large-Scale Trial

Liraglutide 3.0 mg once daily as an adjunct to a reduced-calorie meal plan and physical activity was associated with clinically meaningful and sustained weight loss in a 56-week, randomized, double-blind trial involving more than 3,700 patients who were overweight or obese.

Obesity

Nonsurgical ReShape Integrated Dual Balloon System Now Approved to Treat Obesity

A new balloon device to treat obesity without the need for invasive surgery was approved by the U.S. Food and Drug Administration (FDA). The ReShape Integrated Dual Balloon System works by occupying space in the stomach, which limits the space for food intake and triggers feelings of fullness.

Other Endocrine Disorders

Professionals Singers Return to Performance on Average 2 Months after Thyroid Surgery

In the first study of its kind, researchers found that all 27 consecutive professional voice users (including professional operatic performers) who underwent neural monitored thyroid surgery were able to return to performance, researchers reported in a recent issue of Thyroid.

GLP-1 receptor agonist, liraglutide, promotes weight loss and bone health.

Type 2 Diabetes

Liraglutide May Prevent Weight Loss-Induced Osteoporosis in Women with Diabetes

Treating for type 2 diabetes, the GLP-1 receptor agonist, Liraglutide, promotes weight loss in post-menopausal women and preserves bone health.

New findings suggest that the GLP-1 receptor agonist liraglutide may prevent osteoporosis when used for chronic weight management in post-menopausal women with type 2 diabetes..

Type 1 Diabetes

Increased Risk for Celiac Disease Found Early after Diagnosis of Type 1 Diabetes

People with type 1 diabetes are at increased risk for celiac disease (CD), particularly in the early course of diabetes, according to findings from a systematic review of the literature.

Thyroid cancer

Majority of Supportive Care Needs for Thyroid Cancer Survivors Are Unmet

Most information and support needs among survivors of thyroid cancer are unmet, according to a large online survey reported in the June issue of Thyroid. Key opinion leaders comment on the Morley-Goldfarb study.

Other Endocrine Disorders

Compound in Plastics Linked to Increased Risk of Insulin Resistance in Adolescents

Exposure to urinary metabolites of the phthalate compound di-isononyl phthalate (DINP), which is increasingly used in the manufacturing of consumer products, was linked to an increased risk of high diabetes in adolescents enrolled in a cross-sectional analysis reported in the Journal of Clinical Endocrinology and Metabolism.

Type 1 Diabetes

Clinical Application of the Effects of Fat, Protein, and Glycemic Index on Postprandial Glucose Control

Mealtime insulin dosing calculation should focus on meal composition—including fat, protein, and glycemic index—rather than carbohydrate counting alone, according to a systematic review published in the June issue of Diabetes Care.

Estrogen

Experts Call for Improved Estrogen Testing Accuracy

Unreliable estrogen measurements negatively impact the treatment of and research into many hormone-related cancers and chronic conditions. To improve patient care, a panel of medical experts has called for accurate, standardized estrogen testing methods in a statement published in the Journal of Clinical Endocrinology & Metabolism.

Type 2 Diabetes

Half of Patients With Type 2 Diabetes Have Nonalcoholic Fatty Liver Disease

Commentary by Paola Portillo-Sanchez, MD, and Discussion by Giovanni Targher, MD

Nonalcoholic fatty liver disease (NAFLD) was found in 50% of patients with type 2 diabetes who had normal aminotransferase levels in a recent study reported in the June issue of the Journal of Clinical Endocrinology & Metabolism.

Graves' Disease

Prevalence of Grave’s Disease Varies Widely by Race/Ethnicity

Don McLeod, MD, MPH, PhD, and Terry F. Davies, MD, Comment

Non-Hispanic blacks have a nearly 3-fold higher prevalence of thyrotoxicosis than non-Hispanic whites, according to analysis of data from National Health and Nutritional Examination Surveys (NHANES) reported in the June issue of Thyroid.

Diabetes complications

Study Supports Screening for Diabetes in Dental Offices

Robert J. Genco, DDS, PhD, and Courtney Kloberdanz, DDS, Comment

Screening for diabetes during regular dental visits led to the diagnosis of diabetes and prediabetes in 12.3% and 23.3% of 1,022 patients enrolled in a recent study published in the Journal of the American Dental Association.

Obesity

AMA Approves Resolution to Improve Obesity Education in Medical Schools

Ethan Lazarus, MD, Comments

While obesity is an epidemic in the United States, many physicians receive little training on obesity treatment during medical school. Read this article to find out how the American Medical Association and American Society of Bariatric Physicians are working together to resolve this problem.

$illustration of a hip fracture highlighted in red$

Hyperthyroidism

Subclinical Hyperthyroidism Increases Risk of Hip and Other Fractures

Subclinical hyperthyroidism was associated with an increased risk of hip fracture and other fractures in an observational study involving data from more than 70,000 participants.

Endocrine Research Updates

For Medical Professionals

Professional Resources

Policy and Contact