Endocrine Research Updates

For Medical Professionals

Human stomach
A new balloon device to treat obesity without the need for invasive surgery was approved by the U.S. Food and Drug Administration (FDA). The ReShape Integrated Dual Balloon System works by occupying space in the stomach, which limits the space for food intake and triggers feelings of fullness.
Professional female singer, vocalist
In the first study of its kind, researchers found that all 27 consecutive professional voice users (including professional operatic performers) who underwent neural monitored thyroid surgery were able to return to performance, researchers reported in a recent issue of Thyroid.
GLP-1 receptor agonist, liraglutide, promotes weight loss and bone health.
Treating for type 2 diabetes, the GLP-1 receptor agonist, Liraglutide, promotes weight loss in post-menopausal women and preserves bone health.
New findings suggest that the GLP-1 receptor agonist liraglutide may prevent osteoporosis when used for chronic weight management in post-menopausal women with type 2 diabetes..
People with type 1 diabetes are at increased risk for celiac disease (CD), particularly in the early course of diabetes, according to findings from a systematic review of the literature.
Psychologist giving patient support
Most information and support needs among survivors of thyroid cancer are unmet, according to a large online survey reported in the June issue of Thyroid. Key opinion leaders comment on the Morley-Goldfarb study.
Words related to blood sugar
Exposure to urinary metabolites of the phthalate compound di-isononyl phthalate (DINP), which is increasingly used in the manufacturing of consumer products, was linked to an increased risk of high diabetes in adolescents enrolled in a cross-sectional analysis reported in the Journal of Clinical Endocrinology and Metabolism.
Nutritional labels
Mealtime insulin dosing calculation should focus on meal composition—including fat, protein, and glycemic index—rather than carbohydrate counting alone, according to a systematic review published in the June issue of Diabetes Care.
Vials for samples for lab testing
Unreliable estrogen measurements negatively impact the treatment of and research into many hormone-related cancers and chronic conditions. To improve patient care, a panel of medical experts has called for accurate, standardized estrogen testing methods in a statement published in the Journal of Clinical Endocrinology & Metabolism.
Liver disease
Commentary by Paola Portillo-Sanchez, MD, and Discussion by Giovanni Targher, MD
Nonalcoholic fatty liver disease (NAFLD) was found in 50% of patients with type 2 diabetes who had normal aminotransferase levels in a recent study reported in the June issue of the Journal of Clinical Endocrinology & Metabolism.
Hispanic student getting off schoolbus
Don McLeod, MD, MPH, PhD, and Terry F. Davies, MD, Comment
Non-Hispanic blacks have a nearly 3-fold higher prevalence of thyrotoxicosis than non-Hispanic whites, according to analysis of data from National Health and Nutritional Examination Surveys (NHANES) reported in the June issue of Thyroid.
Regular dental appointment on calendar
Robert J. Genco, DDS, PhD, and Courtney Kloberdanz, DDS, Comment
Screening for diabetes during regular dental visits led to the diagnosis of diabetes and prediabetes in 12.3% and 23.3% of 1,022 patients enrolled in a recent study published in the Journal of the American Dental Association.
Medical education resources
Ethan Lazarus, MD, Comments
While obesity is an epidemic in the United States, many physicians receive little training on obesity treatment during medical school. Read this article to find out how the American Medical Association and American Society of Bariatric Physicians are working together to resolve this problem.
illustration of a hip fracture highlighted in red
Subclinical hyperthyroidism was associated with an increased risk of hip fracture and other fractures in an observational study involving data from more than 70,000 participants.
Words related to clinical trials
Doug Lowy, MD, and Keith T. Flaherty, MD, Comment
The National Cancer Institute (NCI)-supported precision medicine trial known as NCI-MATCH (Molecular Analysis for Therapy Choice) will begin enrollment in July 2015. The goal of the trial is to determine whether select cancer treatments are effective against specific molecular abnormalities, regardless of tumor type. Learn more about the trial and how patients can enroll.
Environmental chemicals are messing with our health.
Avoidance of Endocrine Disrupting Chemicals (EDCs) requires greater due diligence and wiser choices especially with regard to children and pregnant women.
Ongoing exposure to endocrine disrupting chemicals like BPA lead to a number of diseases including diabetes, early onset of puberty, cancer, neurobehavioral disorders, and thyroid disorders.
New Drug Application for MM-398 in Metastatic Pancreatic Cancer
Merrimack Pharmaceuticals, Inc., has submitted a New Drug Application (NDA) for MM-398 (irinotecan liposome injection) in the treatment of patients with metastatic pancreatic cancer who were previously treated with gemcitabine-based therapy. Merrimack has requested a priority review of the NDA.
Bariatric Surgery Before Pregnancy
Bariatric surgery was linked to positive outcomes in pregnancy, such a reduced risk for gestational diabetes and excessive fetal growth, according to data from a population-based study. However, this study was also associated with negative outcomes, including an increased risk for small-for-gestational age infants and possibly increased mortality. These findings suggest the need for increased monitoring during pregnancy.
Earlier Menopause Linked to Exposure to Endocrine Disrupting Chemicals
Women with high levels of endocrine-disrupting chemicals experienced menopause 2 to 4 years earlier than women with lower levels of these chemicals, according to a cross-sectional study using data from using the National Health and Nutrition Examination Survey (NHANES). The findings were published in PLoS ONE.
The t:flex™ Insulin Pump
The t:flex™ Insulin Pump was approved for marketing by the U.S. Food and Drug Administration, making it the largest-capacity insulin pump available in the United States.
Overweight young boy that is upset
Approximately one-quarter to one-third of all children who have obesity and enter weight management programs are depressed, according to 2 studies.