22nd Annual Scientific & Clinical Congress of the American Association of Clinical Endocrinologists:
Gene Expression Classifier and Medullary Thyroid Cancer
A gene expression classifier raised suspicion of Medullary Thyroid Cancer (MTC) in pre-operative fine needle aspiration (FNA) analysis of cytologically indeterminate and malignant neoplasms. A pre-operative diagnosis of MTC may extend importance to evaluation of Multiple Endocrine Neoplasma Type 2 (MEN2) and concurrently existing pheochromocytoma.
More than 10,000 thyroid FNA samples were obtained from several studies:
About the Samples
Gene expression classifier outcomes:
More than 10,000 thyroid FNA samples were obtained from several studies:
- 49 multicenter practice sites (N=4,812)
- One academic center (N=155)
- One academic center ex-vivo (N=172)
- Veracyte CLIA laboratory (N=6,378)
About the Samples
- Samples with inadequate RNA were excluded.
- The gene expression classifier was run prospectively and pre-operatively on all cytologically indeterminant samples.
- A small number of FNAs with malignant cytology were confirmed to be MTC by surgical pathology.
Gene expression classifier outcomes:
- 13 samples "suspicious" for MTC
- 11 samples confirmed as MTC during diagnostic histopathology
- 2 outcomes pending surgery
Next Summary:
Hashimoto's Hypothyroidism Induced by Artificial Sweeteners
Last updated on 06/03/2013
