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Thyroid cancer Research Updates

For Medical Professionals

Research in the field of thyroid disease is thriving with a third of all papers on this topic being published in the last 10 years, according to an analysis in the August issue of Thyroid.
While patients with pT1a and pT1b differentiated thyroid cancer underwent different treatment strategies during the last decade, survival outcomes were similar, according to a retrospective analysis in the August issue of Thyroid.
The targeted therapy with vemurafenib led to partial responses in at least one-third of patients with metastatic thyroid cancer harboring a BRAF mutation, according to an open-label phase 2 clinical study published online ahead of print in Lancet Oncology.
An international panel of experts recommends reclassifying noninvasive encapsulated follicular variant of papillary thyroid carcinoma as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features”. The panel expects the name change to reduce the psychological and medical consequences of a cancer diagnosis in patients with these low-risk tumors.
Although diabetes was not linked to thyroid cancer in our study, diabetes is a major risk factor for cardiovascular disease and some other cancers, and prevention of diabetes is still very important.
In March 2016, the American Thyroid Association Surgical Affairs Committee published a literature review that defines various categories of remote-access thyroid surgery.
Patients with follicular-variant papillary thyroid cancer overall have the least aggressive form of this disease, compared with patients with conventional PTC and tall-cell PTC variants.
A risk-stratified clinical decision-making framework may provide clinicians with a tool to identify which patients are most likely to benefit from an active surveillance management approach for papillary microcarcinoma.
Review of diagnostic slides from cases of follicular thyroid carcinoma diagnosed over the past 50 years resulted in reclassification of nearly three-fourths of cases, according to a study in the journal of Thyroid.
The ThyroSeq v2.1 multigene next generation sequencing test showed a high sensitivity and specificity in the detection of cancer in thyroid nodules with atypia of undetermined significance/follicular lesion of undermined significance (AUS/FLUS) cytology.
New findings from a large prospective cohort add support to the hypothesis that moderate alcohol consumption may lower the risk of papillary and follicular thyroid carcinomas.
Findings suggest that Cyto-I/GEC-B nodules shows comparable clinical behavior to cytologically benign nodules and may be conservatively monitored.
Most information and support needs among survivors of thyroid cancer are unmet, according to a large online survey reported in the June issue of Thyroid. Key opinion leaders comment on the Morley-Goldfarb study.
Repeat fine-needle aspiration following a nondiagnostic result detected malignancy in less than 1% of cases, according to findings reported in the September issue of Radiology. The authors suggest that ultrasound followup may be more appropriate than repeat fine-needle aspiration in patients with initially nondiagnostic results from thyroid nodule biopsy.
A link between autoimmune thyroiditis and differentiated thyroid cancer was found in a surgical series of patients undergoing thyroidectomy but not in a cytological series of patients who underwent fine-needle aspiration, according to findings from a retrospective study published in the September issue of the Journal of Clinical Endocrinology and Metabolism.
EndocrineWeb spoke with Dr. Richard Kloos about the incidence of thyroid nodules and the role of gene expression classifiers. The interview was timely considering that during The Endocrine Society’s annual meeting the American Thyroid Association’s (ATA) preliminary guidelines regarding the management of thyroid nodules were announced.
Research suggests that women diagnosed with differentiated thyroid cancer during pregnancy or soon after are at significantly increased risk for tumor persistence or recurrence compared to women diagnosed when they are not pregnant.
Despite the increasing rates, the death rate from thyroid cancer has remained stable at 0.5 deaths per 100,000 people. The authors suggested that the increasing rates of thyroid cancer may be due to an increase in the detection of subclinical papillary thyroid cancers, which are unlikely to affect patients’ overall health.
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