Insulin injections may be less effective in obese diabetics

In addition to being one of the leading causes of type 2 diabetes, obesity may also impair treatments for the condition, according to Canadian researchers.

In a study published in the journal Diabetes Care, researchers from the University of Sherbrooke reported that obese individuals require much higher doses of insulin and injections take longer to be absorbed by their bodies.

The researchers measured blood flow and insulin absorption in a group of obese diabetes patients and compared the numbers to those of non-obese diabetics. They found that the obese individuals had 64 percent lower adipose tissue blood flow than the non-obese participants. Furthermore, they discovered that this severely limited the absorption of insulin throughout the body.

The poor absorption rate of insulin injections resulted in a delay in the time that it took insulin injections to lower blood sugar levels. This could seriously reduce the effectiveness of one of the most important treatment options that diabetics have.

"Absorption and hypoglycemic action of increasing dosages of lispro are critically delayed in obese subjects with type 2 diabetes," the researchers wrote in their report.
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