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EndocrineWeb Community Advice


From: Alexandra - 3 years 21 weeks ago

Hello everybody.

I would be so grateful to get your input on a problem.

I have been diagnosed with rapid cycling bipolar. New research shows that ppl with rapid cycling BP actually have thyroid disease. We produce enough thyroid hormones. However, our brains can not take up enough of the hormone. So we end up being mentally up and down but physically ok. I hope that makes sense.

Before I started Levothyroxine therapy my TSH: 1.94, Free Thyroxine 13.7 free T3 4.4

Now, I was put on Levothyroxine a month ago on 100, and in the last 30 days I've been increasing. When I hit 250, I noticed that my heart rate was a bit faster and when I went for a walk, I started sweating more than usual after about 10 minutes of walking. I have NO diarrhea, I sleep perfectly fine, I don't feel sick, when I am not moving I am not sweating, and I don't feel hyper etc.

My doctor thinks the heart rate and bit of sweating was because I am scared of taking the medication. This could be true. But I dont know.

Last time I had my blood drawn when I was on 200, my values were the following: TSH 0.02, Free Thyroxine 37.1, Free T3: 8.9

normal range: TSH 0.27-4.2, Free Thyroxine 12.0-22.0, Free T3: 3.1-6.8

I'd love to hear some voices of people what they think of my reaction to Levo given that I had normal thyroid function. How do you think you would feel if your T3 and T4 values were Free Thyroxine 37.1, Free T3: 8.9? Would you have more side effects?

The thing is that people who are truly rapid cycling bipolar have to take up to 600 microgram per day despite previously completely normal TSH, T4 and T3.

Thanks so much for your help!!!


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3 Responses

Is this good advice?

TSH tests have nothing to do with your Thyroid! It tests your pituratary gland in your brain which makes TSH results useless. And get off Levo it comes from Synthroid which is synthetic rather than pure glandular, also levo is a loading storage thyroid medication. You need T4, T3, T2, T1 & T0. Read all the books you can find about your condition because doctors benefit from prescriptions for Synthroid more than their patients do. Educate yourself as much as possible, the quality of your life depends on it.

Is this good advice?

Hi Sbranger,

Thanks for your advice. The thing is, that all the clinical trials on rapid cycling bipolar used Levothyroxine and my Psychiatrist has treated 300 rapid cyclers with Levothyroxine in the past 10 years, successfully. Thus I don't think Levothyroxine is the problem. I just need to have my above question answered to get some peace of mind : )



Is this good advice?

p.s. I've had the T4 to T3 conversion genetic test done. I'm converting ok.