Grazia  Aleppo MD, FACE, FACP's portrait

Grazia Aleppo MD, FACE, FACP

Associate Professor of Medicine - Endocrinology
Northwestern University
Chicago, IL
Dr. Aleppo is a member of the EndocrineWeb Editorial Board.
She is a Senior Editor and oversees the glucose management section of EndocrineWeb.

About Grazia Aleppo MD, FACE, FACP

Grazia Aleppo, MD, FACE is a Clinical Practice Director, Glucose Management Service Director, Assistant Professor of Medicine, and Associate Chief for Clinical Affairs in the Division of Endocrinology, Metabolism, and Molecular Medicine at Northwestern University in Chicago.

Dr. Aleppo currently teaches in both the internal medicine residency program and endocrinology fellowship program at Northwestern University’s Feinberg School of Medicine.

She is a fellow of the American College of Endocrinology and member of several organizations, including The Endocrine Society, American Association of Clinical Endocrinologists (AACE), and the American Diabetes Association (ADA).She has been accredited in thyroid ultrasound and ultrasound-guided fine needle aspiration (FNA) biopsy by the AACE.
She earned her physician and surgeon degree (MD) from the University of Catania, School of Medicine, in Catania, Italy, and completed her endocrinology fellowship at the University of Illinois at Chicago.




Canonico PL, Aronica E, Bruno V, Catania MV, Aleppo G, Galavotti F, Nicoletti F. Pyrrolidonecarboxylic acid magnesium salt (PCA-Mg2+) protects against seizures induced by excitatory amino acids. Functional Neurol. 1990; 5:121-126.
Canonico PL, Aronica E, Aleppo G,Casabona G, Copani A, Favit A, Nicoletti F, Scapagnini U. Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats. Functional Neurol. 1991;6:2:107-111.
Rampello L, Giammona G, Aleppo G,Favit A, Fiore L. Trophic action of Acetyl-L-Carnitine in neuronal cultures. Acta Neurol. 1992;14:1:15-21.
Copani A, Genazzani G, Aleppo G,Canonico PL, Scapagnini U, Nicoletti F. Nootropic drugs positively modulate AMPA-sensitive glutamate receptors in neuronal cultures. J Neurochem. 1992; 58:4:1199-1204.
Sortino MA, Aleppo G, Scapagnini U, Canonico PL. Ipriflavone inhibits phosphoinositide hydrolysis and calcium uptake in the osteoblast-like UMR-106 cells. Eur J Pharmacol. 1992;226:273-277.
Aleppo G,Pisani A, Copani A, Bruno V, Aronica E, D'Agata V, Canonico PL, Nicoletti F. Metabotropic glutamate receptors and neuronal toxicity. Adv Exp Med Biol. 1992;318:137-145.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Parathyroid hormone and arachidonate metabolism. J Endocrinology Invest. 1992;9:27-34.
Canonico PL, Nicoletti F, Sortino MA, Aleppo G, Scapagnini U. Effect of CDP-choline administration on receptor-stimulated inositol phospholipid hydrolysis in brain slices and neuronal cultures. Functional Neurol. 1992;7:275-281.
Nicoletti F, Casabona G, Genazzani AA, Copani A, Aleppo G, Canonico PL, Scapagnini U. Excitatory amino acids and neuronal plasticity: modulation of AMPA receptors as a novel substrate for the action of nootropic drugs. Functional Neurol. 1992;7:413-422.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Acetyl-L-carnitine prevents age-dependent neuroendocrine alterations of reproductive function. Life Sci Adv Exp Clin Endocrinol. 1992;11:101-116.
Di Stefano M, AleppoG, Casabona G, Genazzani AA, Scapagnini U, Nicoletti F. Amyloid beta-protein does not interact with tachykinin receptors coupled to inositol phospholipid hydrolysis in human astrocytoma cells. Brain Res. 1993;600:166-168.
Favit A, Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Protection by dihydroergocryptine of glutamate-induced neurotoxicity. Pharmacol Toxicol. 1993;73:224-228.
Giraldi FP, Mizobuchi M, Horowitz ZD, Downs TR, Aleppo G, Kier A, Wagner T, Yun JS, Kopchick JJ, Frohman LA. Development of neuropithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone promoter-simian virus-40 T-antigen fusion gene. Endocrinology. 1994;134:1219-1224.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone from the GT1-1 neuronal cell line. Endocrinology. 1994;134:1782-1787.
Aleppo G,Nicoletti F, Sortino MA, Casabona G, Scapagnini U, Canonico PL. Chronic L-alpha-Glyceryl-phosphoryl-choline increases inositol phosphate formation in brain slices and neuronal cultures. Pharmacol Toxicol. 1994;74: 95-100.
Aleppo G,Sortino MA, Scapagnini U, Canonico PL. Modulation of hypothalamic protein kinase C activity by alpha -glyceryl-phosphoryl-0-serine. Neuroendocrinol Lett. 1994;16:41-46.
Favit A, Sortino MA, Aleppo G,Scapagnini U, Canonico PL. The inhibition of peroxide formation as a possible substrate for the neuroprotective action of dihydroergocryptine. J Neural Transm. 1994;45: (suppl) 297-305.
Sortino MA, AleppoG, Scapagnini U, Canonico PL. Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging. Brain Res. 1996;41:359-362.
Sortino MA, Aleppo G, Copani A, Casabona G, Nicoletti F, Betra C, Kuhn R, Knoepfel T, Malischek B, Canonico PL. Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cAMP formation. Eur J Neurosci. 1996;8:2407-2415.
Kineman RD, Aleppo G,Frohman LA. The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function. Endocrinology. 1996;137:4630-4636.
Aleppo G, Moskal SF, DeGrandis P, Kineman RD, Frohman LA. Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. Endocrinology. 1997;13:8:1058-1065.
Aleppo G,Copani A, Pisani A, Ratti E, Canonico PL, Nicoletti F. Eccitotossine ambientali e malattie neurodegenerative: studio del meccanismo d'azione della N-metil-beta-amino-L-alanina (BMAA). In: "Ambiente e malattie del Sistema Nervoso", Atti del Primo Congresso Nazionale "Ambiente e Malattie del Sistema Nervoso". Meco G, Bonifati V (eds). Edigraf Srl. 1991:29-34.
Aleppo G,Nicoletti F, Sortino MA, Pisani A, Scapagnini U, Canonico PL. La Neuroprotezione. In: "Vascolare verso metabolico", Atti del Terzo Workshop “La neurosenescenza”. Agnoli A, Scapagnini U, Zanussi C, (eds). Excerpta Medica. Amsterdam, 1992.
Case reports
De Bustros A, Aleppo G, Zikos D. Hypokalemia in Pregnancy: a clue to Gitelman’s syndrome. The Endocrinologist. 2001;11:6:447-450.
Patel V, De Bustros A, Aleppo G. Acute exacerbation of Diabetes and Hypothyroidism in a patient with hepatitis C after therapy with interferon Alpha. The Endocrinologist. 2007;17:157-159.
Valerio F, Sierra M, Duey D, Aleppo G, Tulley J and de Bustros, A. Glycemic control in the medical intensive care unit achieved by implementing a “user friendly” insulin infusion protocol. ACP Illinois Chapter, Chicago, IL, 2004.
Agarwal M, Agarwal G, Aleppo G.Brown tumor as the first manifestation of primary hyperparathyroidism. Endocr Pract. 2006;12:2:90.

Articles Written by Grazia Aleppo MD, FACE, FACP

Insulin Pump: What to Know Before You Disconnect
Find out how to disconnect an insulin pump, plus learn tips on traveling while using an insulin pump and how to safely use an insulin pump at school.
How Do I Use an Insulin Pump?
Grazia Aleppo, MD, associate professor in Medicine-Endocrinology at Northwestern University walks readers through how to use an insulin pump, types of pumps and advantages and disadvantages of using an insulin pump.
Gestational Diabetes: What You Should Know
During pregnancy, some women may develop gestational diabetes but watching your food choices and staying physically active will help you keep your blood sugar levels in the target range.
Insulin Pump Overview
Insulin pumps are small, computerized devices that mimic the way the human pancreas works by delivering small doses of short acting insulin continuously (basal rate).
Thyroid Disease in Pregnancy: What to Know
Two thyroid diseases: hyperthyroidism and hypothyroidism are relatively common in pregnancy and important to treat. Learn why it is important to recognize unusual symptoms so your hormone levels can be monitored, especially during the first trimester.
Early Intensive Treatment Linked to Lower Risk of Death in Type 1 Diabetes
The findings of this important paper emphasize one specific word: early. It is important to treat these patients with type 1 aggressively and early, when they are either adolescent or young adults, or as soon as they are diagnosed if they are diagnosed in their 20s.
Early Intensive Blood Sugar Control Lengthens Life in People with Type 1 Diabetes
Closely controlling blood sugar levels early in the treatment of type 1 diabetes was linked to a lower risk of death later in life, according to findings from a study that followed people with type 1 diabetes for approximately 27 years. The findings were published in the January 6 issue of JAMA.

Articles Reviewed by Grazia Aleppo MD, FACE, FACP

FDA Approves the First Hybrid Artificial Pancreas
09/29/2016 - The U.S. Food and Drug Administration (FDA) yesterday approved the MiniMed 670G, the first so-called “artificial pancreas” – a device that monitors blood sugar and automatically delivers personalized insulin doses to people with type 1 diabetes. 
Dexcom Recall of Continuous Glucose Monitor Receivers
04/18/2016 - Dexcom, Inc., one of the largest makers of continuous glucose monitoring systems (CGMs) in the U.S. is recalling receivers for its G4 Platinum and G5 Mobile CGM systems because of consumer complaints that alarms for low and high blood sugar levels may not sound.
Type 1 Diabetes Vaccine: New Research Looks Promising
06/09/2015 - Researchers announced the approval of a new phase II clinical trial to test whether a vaccine can reverse type 1 diabetes. Details from the study were shared at the American Diabetes Association's 75th Annual Meeting.

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Author's Statement

I, the undersigned, declare that neither I nor members of my immediate family have a financial interests or affiliation with commercial companies whose products and / or services may be mentioned in the materials I have authored, edited or reviewed for presentation on Remedy Health Media, LLC’s websites.
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