Daniel J. Toft MD, PhD

Northwestern University
Chicago, IL

About Daniel J. Toft MD, PhD

Daniel Toft, MD, PhD, is an instructor at Northwestern University in Chicago. He completed his undergraduate education at Brown University before earning his medical degree at the Northwestern University Feinberg School of Medicine. He also earned his PhD from Northwestern, where his research focused on hormones in pregnancy and disease. Currently he is engaged in translational breast cancer research. He has a general endocrinology practice; however, he is especially interested in bone health, adrenal disease, and thyroid disease.



Albert M, Gao Y-M, Toft D, Lee W, Wold A. Photoassisted gold deposition on TiO2 powder. Materials Research Bulletin 27:961-6. 1992.

Ajtai K, Ilich PJ, Ringler A, Sedarous SS, Toft DJ, Burghardt TP. Stereospecific reaction of muscle fiber proteins with the 5' or 6' isomer of (iodoacetamido) tetramethylrhodamine. Biochemistry 31:12431-40. 1992.

Ajtai K, Toft DJ, Burghardt TP. Path and extent of cross-bridge rotation during muscle contraction. Biochemistry 33:5382-91. 1994.

Toft DJ, Linzer DIH. Characterization of novel members of the prolactin/growth hormone family. The Endocrine Society 81st Annual Meeting. (abstract) 1999.

Toft DJ, Linzer DI. Prolactin (PRL)-like protein J, a novel member of the PRL/growth hormone family, is exclusively expressed in maternal decidua. Endocrinology 140:5095-101. 1999.

Lin J, Toft DJ, Bengtson NW, Linzer DI. Placental prolactins and the physiology of pregnancy. Recent Progress in Hormone Research 55:37-51; discussion 52. 2000.

Toft DJ, Linzer DI. Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat. Biology of Reproduction 63:519-25. 2000.

Toft DJ, Rosenberg SB, Bergers G, Volpert O, Linzer DI. Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression. Proceedings of the National Academy of Sciences of the United States of America 98:13055-9. 2001.

Layden BT, Dubner S, Toft DJ, Kopp P, Grimm S, Molitch ME. Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with panhypopituitarism and diabetes insipidus. Pituitary 3 Jan 2009 (Epub ahead of print).

Articles Written by Daniel J. Toft MD, PhD

What Is Graves' Disease?
Graves’ disease is the most common cause of hyperthyroidism, a disorder that causes the thyroid to produce too much thyroid hormone and can cause bulging eyes.
Addison’s Disease and Adrenal Insufficiency Overview
Addison’s disease, a rare disorder, develops when the adrenal glands do not produce enough of the hormone cortisol. Sometimes, the adrenal glands also don’t produce enough of the aldosterone hormone. Includes list of Addison’s disease symptoms.
Types of Diabetic Neuropathy
Neuropathy (nerve damage) can be caused by diabetes. Learn about the four types of diabetic neuropathy, including peripheral, proximal, autonomic and focal.
Graves’ Disease Treatment
Treatment of Graves’ disease may involve anti-thyroid medications, radioactive iodine, and sometimes a partial or total thyroidectomy. The goal of treatment is to bring your overactive thyroid or hyperthyroidism under control.
Healthy Lifestyle Habits During Menopause
Healthy habits, such as exercising, eating a balanced diet, and quitting smoking, are effective ways to manage menopause symptoms. Healthy lifestyle choices will not just improve your menopause transition but your overall quality of life.
Foot Care When You Have Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy often causes people to lose feeling in their feet. Read these helpful tips on good foot care when you have peripheral neuropathy.
Dietary Tips for Osteoporosis Prevention
A healthy, balanced diet rich in calcium and vitamin D (which helps your body absorb calcium) can lower your chances of developing osteoporosis.
Graves’ Disease Diagnosis
In diagnosing Graves’ disease, the doctor will measure the level of different hormones, such as TSH, T3, and T4. Learn what tests you may need to have and what each of the results can tell you about your thyroid condition.
Cushing’s Syndrome Symptoms
In this article, learn about the classic symptoms of Cushing’s syndrome and also how they may differ for men and women.
Acromegaly Surgery
Learn about the different procedures, risks, and goals for acromegaly surgery.
Diabetic Neuropathy Symptoms
Diabetic neuropathy is nerve damage, but the symptoms vary based on what nerves are affected. Common symptoms of peripheral neuropathy include pain and numbness in the feet. Read about symptoms associated with other types of diabetic neuropathy.
Patient Guide to Osteoporosis Prevention
This Patient Guide provides tips on eating right, exercising, and working with your doctor to protect your bones and prevent osteoporosis.
Diabetic Neuropathy Overview
Diabetic neuropathy is nerve damage caused by diabetes. It can be very painful; other symptoms include numbness, tingling, and weakness.
Growth Hormone Therapy
Find out the basics of growth hormone therapy, the most common treatment for growth hormone deficiency, in this article.
Acromegaly Causes
Acromegaly, a growth hormone disorder, is always caused by a benign (non-cancerous) tumor, usually one on the pituitary gland. These tumors are also called adenomas, and they cause the body to produce too much growth hormone.

Articles Reviewed by Daniel J. Toft MD, PhD

Osteoporosis FAQ
Read the answers to some of the most commonly asked questions about osteoporosis & view sources for more detailed articles on specific osteoporosis topics.
Cushing’s Syndrome Causes
Causes of Cushing’s syndrome explained, including pituitary tumors, adrenal tumors, and excessive production of cortisol. Also, use of corticosteroids can cause Cushing’s syndrome.
Osteoporosis Overview
Osteoporosis is a disorder caused by a loss of bone density. When your bones become weak, they become prone to painful fractures. Osteoporosis affects millions of Americans—both men and women—but it is preventable with healthy lifestyle choices.
Warning Signs of Osteoporosis
Article describes warning signs that may indicate low bone mineral density and a heightened risk for developing osteoporosis.
4 Lifestyle Tips for Cushing’s Syndrome
Other than taking medications or having surgery, what else can you do to live well with Cushing’s syndrome? In this article, you’ll learn 4 easy lifestyle tips that can help you thrive with Cushing’s syndrome.
Bracing: An Osteoporosis Treatment Option
Braces help treat osteoporosis-related spinal fractures. They are typically worn for a short period of time because they may prevent you from strengthening your bones. You may also wear a cast or splint if you have a simple wrist fracture.
Osteoporosis Complications
Fractures are the primary complication associated with osteoporosis. Osteoporosis-related fractures typically occur in the wrist, spine, and hips, though any bone can be affected. Spinal compression fractures are especially serious.
Surgery for Pituitary Tumors
Pituitary tumor surgery involves removing all or most of your tumor. But what type of surgery you have depends on what type of tumor you have, as well as the size and shape of the tumor. Article focuses on the 2 main types of pituitary tumor surgery.
Osteoporosis Causes
Osteoporosis does not have a single cause. Lifestyle choices, such as diet and exercise, and biological factors can all lead to osteoporosis.
Osteoporosis Prevention
There are ways you can help prevent osteoporosis, such as exercise, eating a healthy diet rich in calcium and vitamin D, and cutting out smoking.
Estrogen Replacement Therapy for Osteoporosis
Learn about the risks and benefits of estrogen replacement therapy for osteoporosis.
The Role of Calcium and Vitamin D in Bone Health
Calcium and vitamin D are nutrients that help protect you from osteoporosis. Calcium helps build strong bones, while vitamin D ensures that your body effectively absorbs calcium. This overview has daily intake information for calcium and vitamin D.
Surgery for Osteoporosis
Not all fractures require surgery, but serious ones often do. This article explains the different surgical options for hip, spine, and wrist fractures.
Risk Factors for Osteoporosis
Osteoporosis has many risk factors. Some are unavoidable—such as age or a family history of the disease. But there are some risk factors that you do have control over, including eating a nutrient-rich diet and being active.
Osteoporosis Exercise
Just as exercise strengthens muscles, it also strengthens bones. Building strong bones and maintaining them as an adult will help prevent against osteoporosis-related fractures later on. Article overviews exercises that prevent against osteoporosis.

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