Study: Subclinical hypothyroidism may affect lipid profile

According to findings of a recent study presented at the 14th International Thyroid Congress, subclinical hypothyroidism has been shown to have an effect on patterns of lipids in the blood with resulting cardiovascular dysfunction.

"The aim of our study was to compare the lipid profile of one group of patients with subclinical hypothyroidism to assess the effect on the lipid profile and C-reactive protein (CRP) and resulting outcome on endothelium function," wrote O. Pirhaji of the Department of Internal Medicine at Isfahan University of Medical Sciences in Isfahan, Iran.

Doctor's Guide reports that the study looked at 35 patients with subclinical hypothyroid and 103 patients with euthyroid. All patients enrolled were evaluated for triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), total thyroxin, thyrotropin (TSH) and CRP.

The group of patients displaying subclinical hypothyroidism were found to have significantly lower HDL and higher triglycerides in fasting plasma, and higher CRP levels. LDL levels did not differ significantly between the 2 groups.

"These findings demonstrate that subclinical hypothyroidism significantly affects the cardiovascular function and endothelium function by increasing CRP and lipid profiles and suggests that treatment of subclinical hypothyroid in selected subjects recover from these increases following treatment," the authors wrote.