At the Endocrine Society’s 98th Annual Meeting in Boston, Joanna Huang, PharmD presented study findings about patterns of weight loss, weight cycling and weight regain. Dr. Huang is the Senior Manager, Health Economics and Outcome Research at Novo Nordisk, Inc. in Plainsboro, New Jersey.
Obesity is an Epidemic
About the Study
“In order to target treatment for patients, understanding their patterns of weight loss and characteristics of the patients who successfully lost and maintained that weight loss was very important,” commented Dr. Huang. The methodology of this retrospective longitudinal study of patients with obesity (177,743; 1996-2014) used data collected from electronic medical records. The data obtained did not indicate if a patient had undergone bariatric surgery or non-prescribed interventions.
“We first defined the index date as the first observation of any patients who are having a BMI of greater than 30 kg/m2, which we defined as obesity. Then we followed that patient for 6 months to assess their initial weight change. Because we were looking for the long-term maintenance of that initial 6 months weight loss, we then followed the patient for another 2 years,” explained Dr. Huang.
“So in conclusion, despite the level of initial weight loss, weight cycling and regain were commonly observed among patients throughout the 2-year observational period. Weight loss maintenance, even in the moderate and high weight loss groups, is very difficult to achieve. Successful and sustained clinically meaningful weight loss thus requires chronic and effective weight management strategies,” said Dr. Huang.
Disclosure: Joanna Huang, PharmD is an employee of Novo Nordisk, Inc.; Novo Nordisk, Inc. supported this study in collaboration with the Analysis Group.
Huang J. Patterns of Weight Loss, Maintenance, and Gain in Patients with Obesity. OR07-2: Most people cycle and regain weight, and those who lose most are most likely to keep it off. The Endocrine Society’s 98th Annual Meeting & Expo, Boston Convention and Exhibition Center, Boston, MA. April 1, 2016.