Repaglinide and Nateglinide for Type 2 Diabetes

Medications that help the pancreas make more insulin

Written by Lisa M. Leontis RN, ANP-C, Amy Hess-Fischl MS, RD, LDN, BC-ADM, CDE

Repaglinide and nateglinide were developed in 1997. They’re often grouped together, even though they’re technically part of two different classes of medications. Repaglinide is a meglitinide, and nateglinide is a phenylalanine derivative.

How they work: Both repaglinide and nateglinide stimulate the beta cells to make more insulin, just like sulfonylureas. However, unlike sulfonylureas, they’re taken just before eating. They cause your pancreas to produce enough insulin for that meal.
Special notes: Since you’re taking these medications around the time you’re eating, you don’t have to stick to a regular meal schedule, as you do with a sulfonylurea. (Although, it is generally healthier if you maintain a regular, well-balanced meal schedule.) Take these medications only if you are eating a meal.
Examples of these medications:



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