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Type 1 Diabetes Research Updates

For Medical Professionals

People with type 1 diabetes are at increased risk for celiac disease (CD), particularly in the early course of diabetes, according to findings from a systematic review of the literature.
Mealtime insulin dosing calculation should focus on meal composition—including fat, protein, and glycemic index—rather than carbohydrate counting alone, according to a systematic review published in the June issue of Diabetes Care.
DreaMed Diabetes has signed a licensing agreement with Medtronic that will allow its closed-loop artificial pancreas technology, called GlucoSitter™, to be used in Medtronic’s insulin pumps.
Management of type 1 diabetes is particularly challenging during adolescence, a time when teens are dealing with physical changes occurring with puberty, social pressures, and stress, among other issues. In addition, researchers from Columbia University have found that mental health issues including depression, anxiety, and disordered eating are common in teenagers and young adults with type 1 diabetes, and are linked to poorly controlled diabetes.
A clinical trial is examining whether an artificial pancreas improves nighttime blood glucose levels in patients with type 1 diabetes. The study is being conducted by the Icahn School of Medicine at Mount Sinai, New York, NY, and is funded by a grant from JDRF.
Researchers discussed the latest advances in cell replacement therapy for the treatment of type 1 diabetes in the January issue of Endocrinology.
The findings of this important paper emphasize one specific word: early. It is important to treat these patients with type 1 aggressively and early, when they are either adolescent or young adults, or as soon as they are diagnosed if they are diagnosed in their 20s.
Researchers have developed a multistep protocol that converts human embryonic stem cells into insulin-producing cells that can reverse diabetes in approximately 40 days in an animal model—much faster than the 4 months required for cells produced with previous methods. The goal is to be able transplant these insulin-producing cells for the treatment of type 1 diabetes, researchers reported in a study published in the November issue of Nature Biotechnology.
The U.S. Food and Drug Administration (FDA) approved for marketing the first zinc transporter 8 autoantibody (ZnT8Ab) test to aid in the diagnosis of type 1 diabetes.
High albumin levels, but within the normal range, can be used to identify young people with type 1 diabetes at risk of heart and kidney disease, according to a study published online ahead of print in Diabetes Care.

Frequent debridement of chronic wounds is associated with improved healing, according to James Wilcox, RN, lead author of a retrospective study of more than 300,000 wounds.

Study examines high toll the disease takes on patients and families, as well as disconnect between patient and doctor perceptions of quality of life issues.
Researchers examined whether older diabetes patients can benefit from group therapy interventions. Can group settings help improve glycemic control?
Are the long-acting insulin analogs, detemir and glargine, safe and effective in the treatment of pregnant women with type 1 diabetes? A recent study explored this question.
Parental goals for their children’s HbA1c levels may be associated with actual glycemic control in children and adolescents living with type 1 diabetes, according to the results of a new study.
A recent study in Diabetic Medicine explored the association between the transition from pediatric to adult healthcare and children’s self-care and glycemic control.
The extent to which patients are compliant with their type 1 diabetes treatment may have an effect on their mortality risk, according to the results of a recent study in the Journal of Diabetes and its Complications.
In a recent study, researchers explored the effects of both acute and chronic exercise on patients’ management of type 1 diabetes.
Researchers in Australia explored the frequency of decreasing insulin requirements in pregnant women with type 1 diabetes, as well as the effects on newborns. Read the latest updates on this topic here.
More efforts should be made to help reduce the long-term health impacts of poor eating habits in adolescents with type 1 diabetes, according to a recent study.
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