Effects of Hypogonadism Treatment on Patients’ Quality of Life

Men who have late onset hypogonadism may also have lowered psychological well-being and lowered quality of life, according to researchers in China. The team, led by researchers at Peking University People’s Hospital in Beijing, set out to explore the relationship between low testosterone, quality of life, and psychological health.

happy elderly couple riding bicycles together and holding handsThe study, “Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population,” appears in the November 2012 issue of the Chinese Medical Journal.

The researchers looked at data from 160 patients. The participants were split into 2 groups: an active treatment group, which received oral testosterone undecanoate (TU) over the course of 6 months, and a control group which received vitamin E/C capsules for the same amount of time. Participants in the active treatment group received between 120 and 160 mg TU on a daily basis.

The participants were given questionnaires at the beginning of the study and after the 6 months had passed. The questionnaires included: the hospital anxiety and depression scale (HADS), the perceived stress scale (PSS), the short form health survey-12 (SF-12), and the aging male’s symptoms (AMS) rating scale.

The results of the study showed that total serum testosterone concentrations increased after the intervention in the active treatment group. The mean HADS anxiety and depression subscale scores for the participants in the active treatment group decreased at 6 months, compared to the baseline measurement.

Additionally, the mean PSS scores decreased at 6 months, and significant improvements were seen in the SF-12 scores of the patients who were taking TU. The researchers did not find significant changes in the outcomes of the control group at the 6-month follow up.

The researchers argue that their study results demonstrate that androgen replacement helps to both improve the symptoms of androgen deficiency and improve psychological well-being in individuals with hypogonadism.

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