Liver hormone may contribute to insulin resistance and type 2 diabetes

A team of Japanese researchers has discovered that a hormone produced and secreted by the liver may contribute to the development of type 2 diabetes, which may provide a target for the development of future drugs.

The findings, which were published in the journal Cell Metabolism, indicate that individuals who experience insulin resistance have significantly higher levels of a particular hormone produce in the liver. Further testing in lab mice showed that blocking this hormone lowered the occurrence of insulin resistance and type 2 diabetes.

"The current study sheds light on a previously underexplored function of the liver; the liver participates in the pathogenesis of insulin resistance through hormone secretion," said Hirofumi Misu of Kanazawa, who led the study. "Our study raises the possibility that the liver functions as an endocrine organ."



The investigation indicates that fat tissue is one of the main contributors to the development of insulin resistance. Liver hormones have long been known to play a role in the development of this tissue.



Kanazawa added that he hopes the findings will assist in the development of medications that target this hormone and reduce the symptoms of type 2 diabetes.
 
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