Chinese patients with type 2 diabetes may be more prone to developing renal complications

According to research published in the August issue of the Journal of the American Medical Association, four common variants of a gene have been implicated in renal disease development in Chinese patients with type 2 diabetes.

Kidney failure is a common cause of death among diabetic individuals, and Asian populations seem to be particularly at risk. End-stage renal disease (ESRD) occurs very frequently among type 2 diabetics of this ethnicity, and a cell signaling molecule known as PKC-B has been linked to the development of kidney complications.

Lead investigator Ronald Ma and his colleagues from the Chinese University of Hong Kong examined whether variations in this gene are associated with the risk of ESRD.



They evaluated 1,172 Chinese patients with type 2 diabetes who did not have kidney problems at the beginning of the study. After an average of eight years, approximately 7.7 percent of the participants progressed to ESRD.



"In this study, we found that genetic variants of the PKC-B gene were associated with development of incident ESRD independent of other known risk factors," the authors concldued. "Our consistent results thus suggest that genetic variation is an important determinant for the risk of developing [the condition] in Chinese patients with type 2 diabetes."
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