High blood glucose during pregnancy may decrease child’s insulin sensitivity

A study presented at an Endocrine Society meeting reported that women with high levels of blood glucose during pregnancy are more likely to have children with low sensitivity to insulin.

Paula Chandler-Laney and her colleagues from the University of Alabama at Birmingham examined 21 children between the ages of five and 10. The researchers measured their insulin sensitivity and evaluated their mothers’ medical records to determine blood glucose concentration during pregnancy.

They found that a high level of maternal blood sugar is associated with lower insulin sensitivity in the child. This decreased response is a major risk factor for the development of type 2 diabetes.



Although obesity is known to lower sensitivity to this hormone, children in the study experienced the condition independently of their amount of body fat.



“High maternal blood glucose during pregnancy may have lasting effects on children’s insulin sensitivity and secretion, potentially raising the risk for type 2 diabetes,” said Chandler-Lacey. “Obstetricians, pediatricians and pregnant women should all be aware of the potential far-reaching consequences that [this] can have on children’s health.”

These findings were presented on June 22 at the 92nd annual meeting of the Endocrine Society in San Diego.ADNFCR-3583-ID-19924728-ADNFCR
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