Researchers find substance in bone that plays a major role in controlling density

A recent study conducted by the Hebrew University of Jerusalem shows how a group of substances in the body play a key role in controlling bone density. This research has led the team to begin development of a drug for prevention and treatment of osteoporosis and other bone disorders.

In their current research, the scientists found that bone cells produce a series of substances composed of fatty acids and amino acids called "acyl amides." They then analyzed their precise chemical composition, created synthetic versions of them and examined their effect on bone cell cultures.

In experiments on mice, they discovered that one of the compounds in the group of synthetic materials, oleoyl serine, increased bone density in both healthy and osteoporotic mice. They also found that the osteoporotic mice were actually missing the oleoyl serine in their bones.



These findings may serve as the basis for new drugs that can prevent bone loss, boost bone formation and reverse loss of bone tissue in osteoporosis patients.



The findings of the researchers have been published in the Proceedings of the National Academy of Sciences.
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