The Impact of Inactivity on Kids at Risk for Type 2 Diabetes

Are you beginning to bake for the holidays? Please look at our articles on how to cut fat from your recipes.

One last reminder; remember to exercise daily. If you don't have a friendly group with whom you exercise, it's time to get the phone and make arrangements to meet regularly to burn off some calories, tighten up your muscles, and keep your body limber.

Benefits of Breast Feeding
The December issue of Diabetes once again points to the benefits of breast feeding—this time for the mother. Dr. Erica P. Gunderson and her colleagues found that breastfeeding has a "strong protective effect" against metabolic syndrome from the very beginning.

The researchers found that among women with no history of gestational diabetes, those who had breastfed longer than one month were 39-56% less likely to develop metabolic syndrome—depending on how long they had breastfed. Among women with a history of gestational diabetes, breastfeeding for longer than one month was linked to a 44-86% lower risk of metabolic syndrome.

These lower risks took a number of important factors into account—including the women's weight, exercise levels, and the presence of any metabolic components before pregnancy.

Although it is not clear why breastfeeding might lower the risk for developing metabolic syndrome, it may be something to talk over with your physician.

To read the abstract of this research, click here.

Inactivity's Effect on Kids at Risk for Type 2 Diabetes
The December issue of Diabetes also featured an interesting article that once again highlights what happens to at risk children of type 2 diabetics who are inactive in the article, "Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes," by Amra C. Alibegovic et al.

A total of 13 first-degree relatives and 20 matched subjects participated in this study. All were studied before and after 9 days of bed rest using the clamp technique combined with indirect calorimetry (the science of measuring heat caused by physical changes) by an intravenous glucose tolerance test.

The researchers found that bed rest caused a significant decrease in whole-body insulin sensitivity in both groups. Hepatic insulin resistance was elevated in the first-degree relative group prior to bed rest. The rate of whole-body breakdown of fat decreased during the bed rest in both groups, with no significant differences between the groups.

To learn more about this study, click here.

Protecting Beta Cell Function in Type 1 Diabetes
The December issue of Diabetes Care has an article titled, "Effects of Exenatide alone and in combination with Daclizumab on ß-cell function in long-standing type 1 diabetes," by Kristina I Rother, MD, MHSC, et al. The article studied the effects of combining medication with insulin to protect beta cell function in type 1 diabetics.

The researchers examined whether they could improve beta cell function with agents that promote beta cell growth and/or limit beta cell death, or weaken the anti-beta cell autoimmunity.

Twenty people with type 1 diabetes were enrolled in this study. After achieving optimal blood glucose levels, 16 subjects were randomly given insulin therapy with exenatide, and some were given exenatide in combination with the medication daclizumab.

During only exenatide treatment, patients lost an average of 9 lbs. and insulin requirements declined significantly. However the combination of exenatide and daclizumab did not improve function of the remaining beta cells.

To read the abstract of this study, click here.

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