Siri Atma   Greeley MD, PhD's portrait

Siri Atma Greeley MD, PhD

Instructor of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism
The University of Chicago
Chicago, IL

About Siri Atma Greeley MD, PhD

 

Siri Atma Greeley, MD, PhD, is an instructor of pediatrics in the section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism at the University of Chicago. He completed his undergraduate education at Columbia University in New York before earning his medical degree and PhD from the University of Pennsylvania School of Medicine.
 

In his current research, Dr. Greeley hopes to shed light on the spectrum of diabetes in childhood. His focus is on monogenic diabetes (diabetes caused by a single gene mutation), which can be difficult to distinguish from the more common types. Neonatal diabetes that occurs in the first few months of life commonly has an underlying monogenic cause and can often be treated with pills instead of insulin (http://kovlerdiabetescenter.org/registry). Dr. Greeley is helping to establish the University of Chicago as a national center for the study of monogenic diabetes.

 

Publications

 

Abstracts

Greeley SA. Use of a Web-based Registry to Recruit Rare Neonatal Diabetes Patients for Further Study. PAS/LWPES Meeting, Baltimore, May 2009. Abstract Number 751874; Publication Number 178.
 
Greeley SA, Littlejohn E, Li M, Husain AN, Gundeti M, Rosenfield RL. Neonatal Detection of Testicular but not Ovarian Function in True Hermaphroditism (46, XX Ovotesticular DSD). PAS/LWPES Meeting, Baltimore, May 2009. Abstract Number 753745; Publication Number 2828.263.
 
Greeley SA, Stoy J, Lipton RB, Bell GI, Philipson LH. Diagnosis and Treatment of Permanent Neonatal Diabetes Mellitus (PNDM): The University of Chicago Experience. PAS/LWPES Meeting, Hawaii, May 2008. Publication Number 3793.15.
 
Greeley SA, Soos MA, Semple RA, Halac I. A 26-month-old Girl With a Syndrome of Severe Insulin Resistance: Consideration of IGF-1 Therapy. PAS/LWPES Meeting, Hawaii, May 2008. Publication Number 4494.9.
 
Lee SH, Park S, Stoy J, Greeley SA, Wang C, Burnet D, Bell GI. Novel Melanocortin 3 Receptor Gene Mutation in an African-American Child with Severe Obesity. PAS/LWPES Meeting, Hawaii, May 2008. Publication Number 3747.17.
 
Stoy J, Greeley SA, Philipson LH. Diagnosis and treatment of permanent neonatal diabetes mellitus: US experience. PS 2: The spectrum of diabetic disorders. 43rd Annual Meeting of the European Association for the Study of Diabetes. Amsterdam, The Netherlands, September 2007. Abstract Number 0279.
 
Greeley SA, Bordini BD, Edidin DV, Littlejohn EE, Philipson LH. Transition from Insulin to Oral Sulfonylurea Therapy in Children with Diabetes Due to Activating Mutations in KCNJ11. Diabetes. Supplement of 67th Scientific Sessions of the American Diabetes Association, June 2007. Abstract Number: 2763-PO.
 
Greeley SA, Pourbovali A, Shaffer TL, Mencarini M, Lipton RB. Insulin Resistance in Families of Childhood-Onset Diabetes Patients Is Associated with Markers of Cardiovascular Risk and Glucose Control in a Multiethnic Sample. Diabetes. Supplement of 66th Scientific Sessions of the American Diabetes Association, June 2006. Abstract Number: 1796-P.
 
Greeley SA, Pourbovali A, Shaffer TL, Mencarini M, Lipton RB. Phenotype in Childhood-Onset Diabetes Patients Does not Correlate with Familial Insulin Resistance in a Multiethnic Sample. Diabetes. Supplement of 66th Scientific Sessions of the American Diabetes Association, June 2006. Abstract Number: 1797-P.
 
Articles
Kumaraguru J, Flanagan S, Greeley SA, et al. Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes Care. 2009;32(8):1428-30.
 
Stoy J, Greeley SA, Paz VP, et al. Diagnosis and Treatment of Neonatal Diabetes: a United States Experience. Pediatric Diabetes. 2008;9: 45-59.
 
Stoy J, Edghill EL, Flanagan SE, et al. Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci USA. 2007;104(38):15040-15044.
 
Watt C, Greeley SA, Shea JA, Ahn J. Educating future leaders of medical research: analysis of student opinions and goals from the MD-PhD SAGE (Students’ Attitudes Goals and Education) Survey. Academic Medicine. 2007;82(7):633-45.
 
Greeley SA, Katsumata M, Yu L, et al. Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nature Med. 2002;8:399-402.
 
Greeley SA, Moore DJ, Noorchashm H, et al. Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice. J Immunol. 2001;167(8):4351-57.
 
Watt C, Greeley SA, Shea JA, Ahn J. Educational views and attitudes, and career goals of MD-PhD students at the University of Pennsylvania School of Medicine. Academic Medicine. 2005;80(2):193-8.
 
Ahn J, Watt C, Greeley SA, Bernstein J. MD-PhD students in a major training program show strong interest in becoming surgeon-scientists. Clin Orthop Relat Res. 2004;(425):258-63.
 
Moore DJ, Noorchashm H, Lin TH, Greeley SA, Naji A. NOD B-cells are insufficient to incite T-cell-mediated anti-islet autoimmunity. Diabetes. 2005;54(7):2019-25.
 
Noorchashm H, Greeley SA, Naji A. The role of T/B lymphocyte collaboration in the regulation of autoimmune and alloimmune responses. Immunol Res. 2003;27(2-3):443-50.
 
Song HK, Noorchashm H, Lin TH, et al. Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis. J Autoimmun. 2003;21(4):295-303.
 
Noorchashm H, Greeley SA, Naji A. B-cell deficiency and type 1 diabetes. N Engl J Med. 2002;346(7):538-9.
 
Noorchashm H, Lieu YK, Noorchashm N, et al. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet cells of nonobese diabetic mice. J Immunol. 1999;162(5):2467-71.
 
Noorchashm H, Lieu YK, Rostami SY, et al. A direct method for the calculation of alloreactive CD4+ T cell precursor frequency. Transplantation. 1999;67(9):1281-4.
 
Song HK, Noorchashm H, Lieu YK, et al. Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation. J Immunol. 1999;162(5):2467-71.
 

Noorchashm H, Lieu YK, Song HK, et al. B lymphocytes influence the shape of the mature preimmune CD4+ TCR repertoire. Transplant Proc. 1999;31(1-2):832-3.

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Author's Statement

I, the undersigned, declare that neither I nor members of my immediate family have a financial interests or affiliation with commercial companies whose products and / or services may be mentioned in the materials I have authored, edited or reviewed for presentation on Vertical Health, LLC’s websites.
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