| Background: Minimally-Invasive
Radioguided Parathyroidectomy (MIRP) appears to be changing
the the way endocrinologists are treating patients with
hyperparathyridism. Moreover, the frequency with which
endocrinologists refer patients with primary
hyperparathyroidism to a surgeon appears to be increasing
significantly. parathyroid
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Aim: To determine the impact
that MIRP is having on the way endocrinologists treat
hyperparathyroidism. parathyroid
parathyroid parathyroid parathyroid
Methods: The membership of the
American Association of Clinical Endocrinologists was surveyed
by mail regarding physician practices and surgical referral
patterns for hyperparathyroidism. The survey utilized a visual
analog scale (VAS) and multiple-choice questions. The
associations were tested for significance using Chi-square and
logistic regression. Data are meanąSEM.
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Results: The 788 responding
endocrinologists had been practicing for an average of 17
years. They referred an estimated 63% of all patients with
parathyroid overactivity for operative treatment, and
typically utilized localizing studies prior to surgical
referral (Sestamibi scan most commonly).
80% indicated that the availability of MIRP would (or
has already) increase the number of patients referred for
surgery, to near 95% of all of their patients with parathyroid
disease. Endocrinologists identified symptoms, calcium
homeostasis, bone density, health status, risk of general
anesthesia, and patient age as the most important factors in
their decision for surgical referral.
Endocrinologists
also indicated that the availability of MIRP would
change the extent and duration of their preoperative workup
(p<0.0001). In other words, they overwhelmingly stated that
if their patients could have a MIRP rather than a standard
operation, they would order fewer tests and send the patient
for an operation much sooner. Younger endocrinologists
were more likely to refer patients for MIRP (p=0.001) sooner
and thus alter the extent of their preoperative work-up
(p=0.03).
More than 50% of endocrinologists stated that
they had one or more patients who underwent a standard
parathyroid operation who had a significant complication, or
who were not cured by the operation. These
endocrinologists were more anxious to send their patients for
a minimal parathyroid operation (p=0.02).
Finally, when asked if they had to have a
parathyroid operation themselves, 96.5% of all
endocrinologists stated they would have a MIRP rather than a
standard operation (p<0.000001). parathyroid
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Conclusions: These data
confirm the clinical impression seen by the authors (Dr.
Norman, et, al.) that MIRP lowers the threshold to refer
hyperparathyroid patients for surgery. Moreover, MIRP is very
likely to decrease the extent and duration of preoperative
workup while decreasing the time from diagnosis to referral.
Because of the perceived shortcomings of traditional
parathyroidectomy, endocrinologists are rapidly embracing
minimally-invasive parathyroid techniques validated by
disciplined outcomes research |